Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsltm1Alpk mutation
(0 available);
any
Ctsl mutation
(29 available)
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immune system
integument
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• onset of hair loss occurs at weaning with total baldness seen at 8 weeks
• Background Sensitivity: hair loss occurs earlier than in a mixed 129P2/OlaHsd and C57BL/6 background
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• abnormal hair follicle orientation is seen with at least one case where the follicle was oriented parallel to the plane of the epidermis
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• slight epidermal thickening is seen at 4 months
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• abnormal keratinization results in plugs of keratin in the follicles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsltm1Alpk mutation
(0 available);
any
Ctsl mutation
(29 available)
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immune system
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• osteoclast numbers are reduced
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• erosion depth is reduced and the number of trabecular skeletons appear to be decreased
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• at 9 months of age, dermal and hypodermal granulomata are frequently seen
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• occasional subacute folliculitis, sometimes accompanied by subacute dermatitis, is seen
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• ubacute dermatitis is sometimes seen with subacute folliculitis
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skeleton
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• osteoclast numbers are reduced
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• erosion depth is reduced and the number of trabecular skeletons appear to be decreased
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• the amount of trabecular bone is significantly reduced; however following ovariectomy the extent of bone loss is reduced in homozygotes compared to wild-type mice (reduction in bone volume of 27.8% compared to 51.7% in wild-type)
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• the mineralized cartilage zone is disorganized
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• the growth plate appears thinner compared to wild-type mice
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hematopoietic system
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• osteoclast numbers are reduced
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• erosion depth is reduced and the number of trabecular skeletons appear to be decreased
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integument
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• ubacute dermatitis is sometimes seen with subacute folliculitis
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• at weaning, the coat appears dull
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• at 3 months of age progressive hair loss originating dorsally is seen resulting in complete hair loss at 9 months in females; however, males retain some sparse patches of hair
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• at weaning, hair length is reduced
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• at weaning, the coat appears greasy
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• at 3 and 9 months of age, a high incidence of severe hair shaft fragmentation is seen
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• hair follicle expansions containing keratinized debris are seen adjacent and exterior to the sebaceous glands in many homozygotes at 3 months of age
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• occasional subacute folliculitis, sometimes accompanied by subacute dermatitis, is seen
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• at 9 months few anagen follicles are present and those that are appear somewhat atrophic
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• at 9 months of age, diffuse epidermal hyperplasia, with epidermal thickness increased to 4 - 6 cells, is seen
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Allelic
Composition |
Ctsltm1Alpk/Ctsl+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsltm1Alpk mutation
(0 available);
any
Ctsl mutation
(29 available)
|
|
|
skeleton
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• the amount of trabecular bone is significantly reduced; however following ovariectomy the extent of bone loss is reduced in heterozygotes compared to wild-type mice (reduction in bone volume of 36.17% compared to 51.7% in wild-type)
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• the mineralized cartilage zone is disorganized
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integument
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• at 9 months of age, heterozygous females have a bald area covering the central dorsal surface and males have small bald patches
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Analysis Tools