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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cpa3tm1Hrr
targeted mutation 1, Hans-Reimer Rodewald
MGI:3583651
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cpa3tm1Hrr/Cpa3tm1Hrr B6.129P2-Cpa3tm1Hrr MGI:3813556
hm2
 		Cpa3tm1Hrr/Cpa3tm1Hrr involves: 129P2/OlaHsd * C57BL/6 MGI:3584148


Genotype
MGI:3813556
hm1
Allelic
Composition		 Cpa3tm1Hrr/Cpa3tm1Hrr
Genetic
Background		 B6.129P2-Cpa3tm1Hrr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpa3tm1Hrr mutation (0 available); any Cpa3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:125964 )
• all mice die following treatment with ET-1 unlike wild-type mice
increased susceptibility to xenobiotic induced morbidity/mortality ( J:125964 )
• all mice die following treatment with S6b unlike wild-type mice

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:125964 )
• all mice die following treatment with ET-1 unlike wild-type mice
increased susceptibility to xenobiotic induced morbidity/mortality ( J:125964 )
• all mice die following treatment with S6b unlike wild-type mice
increased physiological sensitivity to xenobiotic ( J:125964 )
• all mice die following treatment with S6b unlike wild type mice




Genotype
MGI:3584148
hm2
Allelic
Composition		 Cpa3tm1Hrr/Cpa3tm1Hrr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpa3tm1Hrr mutation (0 available); any Cpa3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell morphology ( J:99367 )
• peritoneal mast cells retain immature histochemical and biochemical hallmarks unlike wild-type cells; however the numbers of peritoneal and skin mast cells, stimulated release of hexosaminidase and histamine, and local passive cutaneous anaphylaxis are normal

hematopoietic system
abnormal mast cell morphology ( J:99367 )
• peritoneal mast cells retain immature histochemical and biochemical hallmarks unlike wild-type cells; however the numbers of peritoneal and skin mast cells, stimulated release of hexosaminidase and histamine, and local passive cutaneous anaphylaxis are normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory