Phenotypes associated with this allele

• Allele Symbol: Hcn2^trls
• Allele Name: tremor and reduced lifespan
• Allele ID: MGI:3582957
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn2^trls/Hcn2^trls	Not Specified	MGI:3615762

Genotype
MGI:3615762

hm1

• Allelic Composition: Hcn2^trls/Hcn2^trls
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:103185 )

• most homozygous mice die at 3 weeks of age, although a few may survive longer

cellular

azoospermia ( J:103185 )

♂ • absent sperm at 3 weeks of age in 3 mutant male mice; one 9 week old mouse did not show this phenotype

behavior/neurological

tremors ( J:103185 )

• tremor in 14 day old pups is similar to that seen with other demyelinating mutations

growth/size/body

decreased body size ( J:103185 )

• smaller body size is evident at 14 days of age

reproductive system

azoospermia ( J:103185 )

♂ • absent sperm at 3 weeks of age in 3 mutant male mice; one 9 week old mouse did not show this phenotype

nervous system

nervous system phenotype ( J:103185 )

N • peripheral and central nervous system myelination appears normal at 9 weeks of age

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:103185 )

• variable penetrance; mild hearing impairment is shown by an increased threshold for high frequency stimuli, but the wave pattern is similar to controls unlike in demyelinating mutations