All Phenotypes Gast<tm1(INS)Ez> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gast^tm1(INS)Ez/Gast⁺	involves: 129S4/SvJae * C57BL/6	MGI:3583902
cx2	Gast^tm1(INS)Ez/Gast⁺ Ins2^Akita/Ins2⁺	involves: 129S4/SvJae * C57BL/6NSlc	MGI:3583903

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal insulin secretion ( J:99270 )

• human insulin is secreted by cells located at the bottom of gastric glands of the antrum in response to ingested small peptides

increased circulating insulin level ( J:99270 )

• gastric peptone instillation induces a 2.2-fold increase in circulating levels of human insulin after 40 minutes

• intragastic lavage of a proton pump inhibitor (omeprazole) induces a 2.3-fold increase in circulating levels of insulin after 4 days of treatment and treatment with both peptone and the proton pump inhibitor together increases blood insulin levels further

improved glucose tolerance ( J:99270 )

• blood glucose levels are about 30% lower 40 minutes after a peptone meal containing 25g/l glucose compared to wild-type mice; however treatment with glucose in the absence of peptone resulted in similar increases in blood glucose in heterozygotes and wild type mice

• heterozygotes are not resistant to streptozotocin-induced diabetes

endocrine/exocrine glands

abnormal insulin secretion ( J:99270 )

• human insulin is secreted by cells located at the bottom of gastric glands of the antrum in response to ingested small peptides

Allelic Composition	Gast^tm1(INS)Ez/Gast⁺ Ins2^Akita/Ins2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6NSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gast^tm1(INS)Ez mutation (1 available); any Gast mutation (18 available)
Ins2^Akita mutation (14 available); any Ins2 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:99270 )

N	• double heterozygotes live over 13 months compared to Ins2^Akita single heterozygotes which have a median survival time of 10.3 months

homeostasis/metabolism

abnormal circulating glucose level ( J:99270 )

• a significant decrease in fasting hyperglycemia is seen in double heterozygotes compared to Ins2^Akita single heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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