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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpa1tm1Wed
targeted mutation 1, Winfried Edelmann
MGI:3582609
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rpa1tm1Wed/Rpa1tm1Wed involves: 129/Sv * C57BL/6J * SJL MGI:3590158
ht2
 		Rpa1tm1Wed/Rpa1+ involves: 129/Sv * C57BL/6J * SJL MGI:3590159


Genotype
MGI:3590158
hm1
Allelic
Composition		 Rpa1tm1Wed/Rpa1tm1Wed
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpa1tm1Wed mutation (0 available); any Rpa1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:99303 )
• homozygous embryos are present at E3.5 but consist of only a few cells and are absent at later times

cellular
decreased cell proliferation ( J:99303 )
• when cultured cells from E3.5 embryos are unable to proliferate




Genotype
MGI:3590159
ht2
Allelic
Composition		 Rpa1tm1Wed/Rpa1+
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpa1tm1Wed mutation (0 available); any Rpa1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99303 )
• heterozygotes have significantly lower survival than their wild-type littermates with loss of heterozygotes beginning around 4 months, greater than 20% loss by 12 months, and about 60% loss by 2 years

neoplasm
increased lymphoma incidence ( J:99303 )
• 9 of 14 heterozygotes developed lymphomas and 4 of these were highly disseminated

immune system
increased lymphocyte cell number ( J:99303 )
• all heterozygotes between 4 and 14 months display marked lymphoid hyperplasia

cellular
chromosome breakage ( J:99303 )
• tumors in heterozygotes contain multiple chromosomal alterations with most showing gains of the entire chromosomes 6 and 15
• heterozygous MEFs have an increased frequency of abnormal karyotypes and chromosomal breaks and impaired double strand break repair

hematopoietic system
abnormal definitive hematopoiesis ( J:99303 )
• hematopoiesis in the bone marrow is abnormal
increased lymphocyte cell number ( J:99303 )
• all heterozygotes between 4 and 14 months display marked lymphoid hyperplasia




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory