Phenotypes associated with this allele

• Allele Symbol: Itgal^tm1Hlz
• Allele Name: targeted mutation 1, Bernhard Holzmann
• Allele ID: MGI:3582587
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgal^tm1Hlz/Itgal^tm1Hlz	involves: 129P2/OlaHsd	MGI:3583783

Genotype
MGI:3583783

hm1

• Allelic Composition: Itgal^tm1Hlz/Itgal^tm1Hlz
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cellular extravasation ( J:99286 )

• lymphocytes from spleen or lymph nodes were impaired in their capacity to transmigrate bEnd5 endothelial cell monolayers

abnormal leukocyte adhesion ( J:99286 )

• adhesion of unstimulated thymocytes to a recombinant ICAM-1(D1-2)-Fc was elevated

spleen hyperplasia ( J:99286 )

• spleen cell numbers are significantly greater

decreased neutrophil cell number ( J:99286 )

• in induced aseptic peritonitis response, neutrophil numbers were reduced indicating impaired inflammatory cell recruitment

decreased lymphocyte cell number ( J:99286 )

• total cell numbers in peripheral lymph nodes and Peyer's patches are reduced substantially

• bone marrow and thymus cellularity as well as peripheral blood leukocyte numbers were not altered

decreased cytotoxic T cell cytolysis ( J:99286 )

• lytic activity are impaired, but the generation of CD8 T cells are normal

abnormal T cell activation ( J:99286 )

• T cell activation by superantigen-pulsed or allogenic APCs is impaired markedly

abnormal humoral immune response ( J:99286 )

• T cell-dependent humoral immune responses are attenuated

hematopoietic system

abnormal cellular extravasation ( J:99286 )

• lymphocytes from spleen or lymph nodes were impaired in their capacity to transmigrate bEnd5 endothelial cell monolayers

abnormal leukocyte adhesion ( J:99286 )

• adhesion of unstimulated thymocytes to a recombinant ICAM-1(D1-2)-Fc was elevated

spleen hyperplasia ( J:99286 )

• spleen cell numbers are significantly greater

decreased neutrophil cell number ( J:99286 )

• in induced aseptic peritonitis response, neutrophil numbers were reduced indicating impaired inflammatory cell recruitment

decreased lymphocyte cell number ( J:99286 )

• total cell numbers in peripheral lymph nodes and Peyer's patches are reduced substantially

• bone marrow and thymus cellularity as well as peripheral blood leukocyte numbers were not altered

decreased cytotoxic T cell cytolysis ( J:99286 )

• lytic activity are impaired, but the generation of CD8 T cells are normal

abnormal T cell activation ( J:99286 )

• T cell activation by superantigen-pulsed or allogenic APCs is impaired markedly

cellular

abnormal cellular extravasation ( J:99286 )

• lymphocytes from spleen or lymph nodes were impaired in their capacity to transmigrate bEnd5 endothelial cell monolayers

abnormal leukocyte adhesion ( J:99286 )

• adhesion of unstimulated thymocytes to a recombinant ICAM-1(D1-2)-Fc was elevated

growth/size/body

spleen hyperplasia ( J:99286 )

• spleen cell numbers are significantly greater