About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgre1tm1Stst
targeted mutation 1, Joan Stein-Streilein
MGI:3582333
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adgre1tm1Stst/Adgre1tm1Stst B6.129S1-Emr1tm1Stst MGI:3582731


Genotype
MGI:3582731
hm1
Allelic
Composition		 Adgre1tm1Stst/Adgre1tm1Stst
Genetic
Background		 B6.129S1-Emr1tm1Stst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgre1tm1Stst mutation (1 available); any Adgre1 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal regulatory T cell physiology ( J:99213 )
• in a low-dose oral tolerance model, homozygous null mice were not able to generate an efferent CD+ T reg cell population that suppressed an antigen-specific DTH response
abnormal immune tolerance ( J:99213 )
• in the anterior chamber-associated immune deviation (ACAID) model of peripheral tolerance, anterior chamber inoculation of antigen was unable to induce efferent regulatory T (T reg) cells and suppress delayed-type hypersensitivity (DTH) responses

hematopoietic system
abnormal regulatory T cell physiology ( J:99213 )
• in a low-dose oral tolerance model, homozygous null mice were not able to generate an efferent CD+ T reg cell population that suppressed an antigen-specific DTH response




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory