Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation
(2 available);
any
Gfap mutation
(47 available)
Tg(GFAP)10Mes mutation
(0 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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mortality/aging
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N |
• all animals survive compared to Tg(GFAP-Cryab)141.6Mes-positive double mutants which die around 30 days of age
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nervous system
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• Rosenthal fibers are observed, but numbers are significantly less than in Gfaptm2Hgmn/+/Tg(GFAP)10Mes animals; both soluble and insoluble GFAP levels are reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• two thirds of mice null for Cryab show survival to 100 days compared to Cryab-sufficient Tg(GFAP)10Mes mice which display <10% mortality at about 30 days of age; around 30% of animals die at about 30 days of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(9Hspb2-Cryab)1Wawr mutation
(0 available);
any
Del(9Hspb2-Cryab)1Wawr mutation
(0 available)
Tg(GFAP)10Mes mutation
(0 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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mortality/aging
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• majority of animals (about 90%) survive to 3 months of age
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growth/size/body
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N |
• mice show significantly increased body weights at 6 weeks and three months relative to Tg(GFAP)10Mes and Tg(GFAP)10/Tg(GFAP-Cryab)141.6Mes Cryab-null animals; weights are comparable to wild-type
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nervous system
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• Rosenthal fibers which outline astrocytic processes are present in mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• one third of mice null for Cryab show survival to 100 days compared to Cryab-sufficient Tg(GFAP)10Mes mice which display <10% mortality at about 30 days of age; most animals die at about 30 days of age
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growth/size/body
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• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type
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nervous system
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• by 3 months of age, animals show formation of ubiquinated astrocytic protein (Rosenthal fiber) aggregates in the hippocampus (dentate gyrus and near pial surface of superior colliculus)
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Allelic
Composition |
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
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Genetic
Background |
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation
(2 available);
any
Gfap mutation
(47 available)
Tg(GFAP)10Mes mutation
(0 available)
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mortality/aging
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• almost all die at around 30 days of age
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nervous system
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• two mutants exhibit seizure-like episodes before death
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• at 24 days of age, exhibit increased Rosenthal fiber formation and higher levels of insoluble Gfap than either single mutant
• astrocytes are hypertrophied in the regions of brain that normally show high levels of Gfap expression
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behavior/neurological
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• two mutants exhibit seizure-like episodes before death
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation
(2 available);
any
Gfap mutation
(47 available)
Tg(GFAP)10Mes mutation
(0 available)
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mortality/aging
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• all animals die by under 50 days of age (most die around 30 days)
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nervous system
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• Rosenthal fiber formation is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP)10Mes mutation
(0 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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cellular
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• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfaptm2Hgmn/+/+ mice
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Allelic
Composition |
Tg(GFAP)10Mes/0
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Genetic
Background |
involves: FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• mice display <10% mortality at about 30 days of age
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• severely affected mice die around 14 days of age; less affected mice live for more than 1 year
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growth/size/body
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• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type
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nervous system
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• astrocytes are enlarged and contain large eosinophilic aggregations resembling Rosenthal fibers;
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Analysis Tools