Phenotypes associated with this allele

• Allele Symbol: Tlx1^tm1Thr
• Allele Name: targeted mutation 1, Terence H Rabbitts
• Allele ID: MGI:3581680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlx1^tm1Thr/Tlx1^tm1Thr	involves: 129P2/OlaHsd * MF1	MGI:3582411

Genotype
MGI:3582411

hm1

• Allelic Composition: Tlx1^tm1Thr/Tlx1^tm1Thr
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased splenocyte apoptosis ( J:28700 )

• at E12.5, a significant number of spleen cells undergo apoptosis

abnormal spleen development ( J:28700 )

• a spleen anlage is present at E11.5 but undergoes rapid and complete resorption between E12.5 and E13.5

absent spleen ( J:28700 )

• homozygotes are born without a spleen

• however, homozygous mutant mice can survive to birth, develop normally, and are fertile

immune system

increased splenocyte apoptosis ( J:28700 )

• at E12.5, a significant number of spleen cells undergo apoptosis

abnormal spleen development ( J:28700 )

• a spleen anlage is present at E11.5 but undergoes rapid and complete resorption between E12.5 and E13.5

absent spleen ( J:28700 )

• homozygotes are born without a spleen

• however, homozygous mutant mice can survive to birth, develop normally, and are fertile

cellular

increased splenocyte apoptosis ( J:28700 )

• at E12.5, a significant number of spleen cells undergo apoptosis