All Phenotypes Slamf6<tm1Dhow> MGI Mouse

abnormal neutrophil physiology ( J:98995 )

• polymorphonuclear neutrophils produce 5-fold more IL-12p40, 2-fold more TNF and moderately more IL-16; however cytokine production by macrophages is normal

impaired granulocyte bactericidal activity ( J:98995 )

• neutrophil bactericidal activity but not phagocytosis is impaired and the production of reactive oxygen species in response to heat killed E. coli is severely reduced; however, the bactericidal activity of macrophages is normal

abnormal T-helper 2 physiology ( J:98995 )

• Th2 functions are impaired

increased circulating interleukin-12b level ( J:98995 )

• after infection with Salmonella tymphimurium circulating levels of IL-12p40 are increased 4- to 7-fold

increased circulating interleukin-16 level ( J:98995 )

• after infection with Salmonella tymphimurium circulating levels of IL-16 are increased 4- to 7-fold

increased circulating tumor necrosis factor level ( J:98995 )

• after infection with Salmonella tymphimurium circulating levels of TNF are increased 4- to 7-fold

decreased interleukin-4 secretion ( J:98995 )

• splenic CD4+ T cells produce less IL-4 in vitro even after PMA/ionomycin stimulation of under Th2 polarizing conditions and in vivo after infection with Leishmania mexicana

increased susceptibility to bacterial infection ( J:98995 )

• 24 hours after infection with a mutant strain of Salmonella tymphimurium with attenuated virulence homozygotes display signs of severe salmonellosis while wild-type mice appear healthy

increased susceptibility to bacterial infection induced morbidity/mortality ( J:98995 )

• 40% of homozygotes compared to no wild-type mice die 24 hours after infection with a mutant strain of Salmonella tymphimurium with attenuated virulence

• morbidity is accelerated following infection with Salmonella tymphimurium strain S14028 with 100% of homozygotes dead at 3 days compared to 5 days for wild-type mice

decreased susceptibility to parasitic infection ( J:98995 )

• after infection with Leishmania mexicana lesions are smaller and lesion formation is delayed