Analysis Tools
normal phenotype
|
• transgenic mice with no cre expression developed normally with no significant cardiac phenotype
|
|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-GFP,MAP2K3)58Ywa transgene insertion 58, Yibin Wang MGI:3581033 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• transgenic mice with no cre expression developed normally with no significant cardiac phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• hemizygous or homozygous mice for Tg(Myh6-GFP,MAP2K3)58Ywa that are also heterozygous for Myl2tm1(cre)Krc, in which cre mediated recombination is induced in cardiac muscle, display premature death between 5 and 7 weeks of age
|
|
• pulmonary edema
|
|
• sign of dyspnea around time of death
|
|
• pulmonary edema
|
|
• heterogeneous myocyte atrophy
|
|
• profoundly enlarged atria
|
|
• increased atrial mass often filled with thrombosis
• external dimensions, and mass of ventricles are normal
|
|
• trichrome staining shows substantial interstitial fibrotic tissues
|
|
• systolic contractile depression and restrictive diastolic abnormalities
• increased end-systolic chamber volumes
|
|
• heterogeneous myocyte atrophy
|
|
• increased atrial mass often filled with thrombosis
• external dimensions, and mass of ventricles are normal
|
|
• trichrome staining shows substantial interstitial fibrotic tissues
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||