Phenotypes associated with this allele

• Allele Symbol: Cox7a1^tm1Hutt
• Allele Name: targeted mutation 1, Maik Huttemann
• Allele ID: MGI:3580679
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cox7a1^tm1Hutt/Cox7a1^tm1Hutt	B6.129-Cox7a1^tm1Hutt	MGI:5465105
ht2	Cox7a1^tm1Hutt/Cox7a1^+	B6.129-Cox7a1^tm1Hutt	MGI:5465106

Genotype
MGI:5465105

hm1

• Allelic Composition: Cox7a1^tm1Hutt/Cox7a1^tm1Hutt
• Genetic Background: B6.129-Cox7a1^tm1Hutt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:192141 )

• in 4 of 75 mice

cardiovascular system

cardiovascular system phenotype ( J:192141 )

N • atrium size is normal

increased heart left ventricle weight ( J:192141 )

• 1.5-fold at 1 month

• at 6 to 9 weeks

dilated cardiomyopathy ( J:192141 )

decreased heart ventricle muscle contractility ( J:192141 )

• systolic and diastolic

cellular

abnormal cellular respiration ( J:192141 )

• heart mitochondria exhibit reduced respiratory control ratio compared with control mitochondria

muscle

dilated cardiomyopathy ( J:192141 )

decreased heart ventricle muscle contractility ( J:192141 )

• systolic and diastolic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:192141

Genotype
MGI:5465106

ht2

• Allelic Composition: Cox7a1^tm1Hutt/Cox7a1⁺
• Genetic Background: B6.129-Cox7a1^tm1Hutt

cardiovascular system

decreased heart ventricle muscle contractility ( J:192141 )

• decreased ventricular ejection fraction

muscle

decreased heart ventricle muscle contractility ( J:192141 )

• decreased ventricular ejection fraction