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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cox7a1tm1Hutt
targeted mutation 1, Maik Huttemann
MGI:3580679
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cox7a1tm1Hutt/Cox7a1tm1Hutt B6.129-Cox7a1tm1Hutt MGI:5465105
ht2
 		Cox7a1tm1Hutt/Cox7a1+ B6.129-Cox7a1tm1Hutt MGI:5465106


Genotype
MGI:5465105
hm1
Allelic
Composition		 Cox7a1tm1Hutt/Cox7a1tm1Hutt
Genetic
Background		 B6.129-Cox7a1tm1Hutt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox7a1tm1Hutt mutation (0 available); any Cox7a1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:192141 )
• in 4 of 75 mice

cardiovascular system
cardiovascular system phenotype ( J:192141 )
N
• atrium size is normal
increased heart left ventricle weight ( J:192141 )
• 1.5-fold at 1 month
• at 6 to 9 weeks
decreased ventricle muscle contractility ( J:192141 )
• systolic and diastolic

cellular
abnormal cellular respiration ( J:192141 )
• heart mitochondria exhibit reduced respiratory control ratio compared with control mitochondria

muscle
decreased ventricle muscle contractility ( J:192141 )
• systolic and diastolic

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
 J:192141




Genotype
MGI:5465106
ht2
Allelic
Composition		 Cox7a1tm1Hutt/Cox7a1+
Genetic
Background		 B6.129-Cox7a1tm1Hutt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox7a1tm1Hutt mutation (0 available); any Cox7a1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased ventricle muscle contractility ( J:192141 )
• decreased ventricular ejection fraction

muscle
decreased ventricle muscle contractility ( J:192141 )
• decreased ventricular ejection fraction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory