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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrm1tm1Kano
targeted mutation 1, Masanobu Kano
MGI:3580391
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chrm1tm1Kano/Chrm1tm1Kano involves: 129X1/SvJ MGI:3616715
hm2
 		Chrm1tm1Kano/Chrm1tm1Kano involves: 129X1/SvJ * C57BL/6 MGI:3581874
hm3
 		Chrm1tm1Kano/Chrm1tm1Kano involves: 129X1/SvJ * C57BL/6J MGI:4443055
cx4
 		Chrm1tm1Kano/Chrm1tm1Kano
Chrm3tm1Mmt/Chrm3tm1Mmt 		involves: 129X1/SvJ * C57BL/6 MGI:3581877
cx5
 		Chrm1tm1Kano/Chrm1tm1Kano
Chrm5tm1Minm/Chrm5tm1Minm 		involves: 129X1/SvJ * C57BL/6 MGI:3616717


Genotype
MGI:3616715
hm1
Allelic
Composition		 Chrm1tm1Kano/Chrm1tm1Kano
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm1Kano mutation (0 available); any Chrm1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:105126 )
N
• carbachol-induced intracellular calcium concentration increases in submandibular gland cells are indistinguishable from wild-type and homozygotes do not show frequent prandial drinking, indicating normal salivation




Genotype
MGI:3581874
hm2
Allelic
Composition		 Chrm1tm1Kano/Chrm1tm1Kano
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm1Kano mutation (0 available); any Chrm1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inhibitory postsynaptic currents ( J:98902 )
• hippocampal neuron pairs exhibit a reduction in the enhanced depolarization-induced suppression of inhibitory (DSI) postsynaptic currents in response to the muscarinic agonist oxotremorine-M




Genotype
MGI:4443055
hm3
Allelic
Composition		 Chrm1tm1Kano/Chrm1tm1Kano
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm1Kano mutation (0 available); any Chrm1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:104782 )
N
• normal intragastric pH, normal carbachol-, histamine-, or gastrin-stimulated gastric acid secretion, and normal serum gastrin and gastric histamine levels




Genotype
MGI:3581877
cx4
Allelic
Composition		 Chrm1tm1Kano/Chrm1tm1Kano
Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm1Kano mutation (0 available); any Chrm1 mutation (26 available)
Chrm3tm1Mmt mutation (0 available); any Chrm3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inhibitory postsynaptic currents ( J:98902 )
• hippocampal neuron pairs do not exhibit an enhanced depolarization-induced suppression of inhibitory (DSI) postsynaptic currents in response to the muscarinic agonist oxotremorine-M as was seen in controls

digestive/alimentary system
abnormal submandibular gland physiology ( J:105126 )
• carbachol-induced intracellular calcium concentration increase is completely absent in submandibular gland cells, however phenylephrine, an alpha1-adrenergic agonist, induces similar calcium responses as in wild-type
decreased salivation ( J:105126 )
• a high dose of pilocarpine induces almost no salivation compared to wild-type

endocrine/exocrine glands
abnormal submandibular gland physiology ( J:105126 )
• carbachol-induced intracellular calcium concentration increase is completely absent in submandibular gland cells, however phenylephrine, an alpha1-adrenergic agonist, induces similar calcium responses as in wild-type
decreased salivation ( J:105126 )
• a high dose of pilocarpine induces almost no salivation compared to wild-type

homeostasis/metabolism
decreased salivation ( J:105126 )
• a high dose of pilocarpine induces almost no salivation compared to wild-type




Genotype
MGI:3616717
cx5
Allelic
Composition		 Chrm1tm1Kano/Chrm1tm1Kano
Chrm5tm1Minm/Chrm5tm1Minm
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm1Kano mutation (0 available); any Chrm1 mutation (26 available)
Chrm5tm1Minm mutation (0 available); any Chrm5 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased digestive secretion ( J:104782 )
• decrease in gastric acid secretion in response to carbachol, with a significant decrease in cumulative acid output compared to wild type
• however gastric mucosal histology is normal

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:105126 )
N
• no difference in pilocarpine-induced salivation from wild-type or in the frequency of prandial drinking, indicating normal salivation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory