Phenotypes associated with this allele

• Allele Symbol: Tbx20^tm1Akis
• Allele Name: targeted mutation 1, Andreas Kispert
• Allele ID: MGI:3580099
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx20^tm1Akis/Tbx20^tm1Akis	involves: 129S1/SvImJ * NMRI	MGI:3580155

Genotype
MGI:3580155

hm1

• Allelic Composition: Tbx20^tm1Akis/Tbx20^tm1Akis
• Genetic Background: involves: 129S1/SvImJ * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98806 )

• homozygotes die around E10.5

cardiovascular system

abnormal vascular development ( J:98806 )

• vessels development is impaired

abnormal heart development ( J:98806 )

failure of heart looping ( J:98806 )

• heart development arrests at the linear tube stage (E8.5)

abnormal heart tube morphology ( J:98806 )

• at E9.5 the heart tube fails to elongate and has two constrictions separating the putative ventricle from the inflow and outflow tract regions

• endocardial cushion accumulates at the anterior constriction disrupting the continuity of the endocardial lining

• dorsoventral patterning and chamber differentiation are absent in mutant hearts

abnormal blood circulation ( J:98806 )

• blood circulation is absent

decreased fetal cardiomyocyte proliferation ( J:98806 )

• cardiomyocyte proliferation is significantly reduced at E8.5-E8.75; however proliferation in the extracardiac regions is normal at this time

embryo

embryonic growth arrest ( J:98806 )

• cellular proliferation in all tissues is arrested at E9.5

embryonic growth retardation ( J:98806 )

• severe growth retardation seen at E9.5

homeostasis/metabolism

edema ( J:98806 )

muscle

decreased fetal cardiomyocyte proliferation ( J:98806 )

• cardiomyocyte proliferation is significantly reduced at E8.5-E8.75; however proliferation in the extracardiac regions is normal at this time

growth/size/body

embryonic growth retardation ( J:98806 )

• severe growth retardation seen at E9.5

cellular

decreased fetal cardiomyocyte proliferation ( J:98806 )

• cardiomyocyte proliferation is significantly reduced at E8.5-E8.75; however proliferation in the extracardiac regions is normal at this time