All Phenotypes Tbx20<tm1.1Rph> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx20^tm1.1Rph
targeted mutation 1.1, Richard P Harvey
MGI:3579836

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx20^tm1.1Rph/Tbx20^tm1.1Rph	involves: C57BL/6	MGI:3579844
ht2	Tbx20^tm1.1Rph/Tbx20⁺	involves: C57BL/6	MGI:3579845
cx3	Nkx2-5^tm4Rph/Nkx2-5^tm4Rph Tbx20^tm1.1Rph/Tbx20^tm1.1Rph	involves: 129S1/Sv * C57BL/6	MGI:3579846
cx4	Nkx2-5^tm4Rph/Nkx2-5⁺ Tbx20^tm1.1Rph/Tbx20⁺	involves: 129S1/Sv * C57BL/6	MGI:3579847
cx5	Nkx2-5^tm3Rph/Nkx2-5⁺ Tbx20^tm1.1Rph/Tbx20⁺	involves: C57BL/6	MGI:3716381

Allelic Composition	Tbx20^tm1.1Rph/Tbx20^tm1.1Rph
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx20^tm1.1Rph mutation (1 available); any Tbx20 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98489 )

• death at E10.5

cardiovascular system

failure of heart looping ( J:98489 )

• looping is blocked

abnormal heart tube morphology ( J:98489 )

• at E8.5 and E9.5 severely decreased expression of chamber specific markers indicates a lack of chamber differentiation

• at E9.5 two small chamber-like swellings separated by a circumferential sulcus are seen which lack trabeculae and endocardial cushions and the heart is small, forward looped, and hourglass shaped

decreased fetal cardiomyocyte proliferation ( J:98489 )

• at E9.0 the mitotic index in the outflow and inflow ventricle-like chambers are reduced 6- to 7-fold and 2.2 to 3.3-fold, respectively

embryo

abnormal visceral yolk sac mesenchyme morphology ( J:98489 )

• elevated apoptosis is seen in the mesodermal layer at E9.5

abnormal vitelline vascular remodeling ( J:98489 )

• the yolk sac vascular plexus forms but is not remodeled into mature vessels

muscle

decreased fetal cardiomyocyte proliferation ( J:98489 )

• at E9.0 the mitotic index in the outflow and inflow ventricle-like chambers are reduced 6- to 7-fold and 2.2 to 3.3-fold, respectively

growth/size/body

abnormal body wall morphology ( J:98489 )

• delayed closure of the foregut pocket

cellular

decreased fetal cardiomyocyte proliferation ( J:98489 )

• at E9.0 the mitotic index in the outflow and inflow ventricle-like chambers are reduced 6- to 7-fold and 2.2 to 3.3-fold, respectively

Allelic Composition	Tbx20^tm1.1Rph/Tbx20⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx20^tm1.1Rph mutation (1 available); any Tbx20 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart left atrium ( J:98489 )

• left atrial dilation is seen

decreased heart left ventricle wall thickness ( J:98489 )

• left ventricular wall thickness was decreased by 35%

dilated heart left ventricle ( J:98489 )

• the left ventricle diastolic dimension is mildly but significantly increased

dilated cardiomyopathy ( J:98489 )

• signs of dilated cardiomyopathy are seen but no compensatory myocardial hypertrophy or change in heart weight are detected

decreased heart left ventricle muscle contractility ( J:98489 )

• left ventricular systolic dimension was increased 42% and fractional shortening was decreased by 21%

muscle

dilated cardiomyopathy ( J:98489 )

• signs of dilated cardiomyopathy are seen but no compensatory myocardial hypertrophy or change in heart weight are detected

decreased heart left ventricle muscle contractility ( J:98489 )

• left ventricular systolic dimension was increased 42% and fractional shortening was decreased by 21%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:98489

Allelic Composition	Nkx2-5^tm4Rph/Nkx2-5^tm4Rph Tbx20^tm1.1Rph/Tbx20^tm1.1Rph
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm4Rph mutation (2 available); any Nkx2-5 mutation (21 available)
Tbx20^tm1.1Rph mutation (1 available); any Tbx20 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart tube morphology ( J:98489 )

• double homozygous mice show a combination of the heart abnormalities seen in single homozygotes

Allelic Composition	Nkx2-5^tm4Rph/Nkx2-5⁺ Tbx20^tm1.1Rph/Tbx20⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:98489 )

• only 10% of mice at weaning were double heterozygotes suggesting partial embryonic or perinatal lethality

cardiovascular system

myocardial fiber disarray ( J:98489 )

• some adult mice with atrial septal defects also display myocyte disarray

dilated heart left atrium ( J:98489 )

• left atrial dilation is seen

atrial septal defect ( J:98489 )

• 16% of double heterozygotes had atrial septal defects

decreased heart left ventricle wall thickness ( J:98489 )

• left ventricular wall thickness was decreased by 40%

dilated heart left ventricle ( J:98489 )

• the left ventricle diastolic dimension is mildly but significantly increased

cardiac fibrosis ( J:98489 )

• some adult mice with atrial septal defects also display patches of fibrosis in the right ventricular myocardium

dilated cardiomyopathy ( J:98489 )

• signs of dilated cardiomyopathy are seen but no compensatory myocardial hypertrophy or change in heart weight are detected

decreased heart left ventricle muscle contractility ( J:98489 )

• left ventricular systolic dimension was increased 47% and fractional shortening was decreased by 24%

muscle

myocardial fiber disarray ( J:98489 )

• some adult mice with atrial septal defects also display myocyte disarray

dilated cardiomyopathy ( J:98489 )

• signs of dilated cardiomyopathy are seen but no compensatory myocardial hypertrophy or change in heart weight are detected

decreased heart left ventricle muscle contractility ( J:98489 )

• left ventricular systolic dimension was increased 47% and fractional shortening was decreased by 24%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrial heart septal defect 1		DOID:0110106	OMIM:108800	J:98489

Allelic Composition	Nkx2-5^tm3Rph/Nkx2-5⁺ Tbx20^tm1.1Rph/Tbx20⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm3Rph mutation (0 available); any Nkx2-5 mutation (21 available)
Tbx20^tm1.1Rph mutation (1 available); any Tbx20 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart right ventricle ( J:98489 )

cardiac fibrosis ( J:98489 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24