Analysis Tools
mortality/aging
|
• about one-third of mutant mice died between 20 and 30 days
• mutants that survived past 1 month of age rarely died prematurely
|
nervous system
| N |
• homozygous mutant mice that are heterozygous for Cnp1tm1(cre)Kan, in which cre mediated recombination is induced in oligodendrocyte and Schwann cells, were normal at birth
• did not reveal any obvious oligodendrocytes loss, or apoptosis
|
demyelination
(
J:98525
)
|
• severe dysmyelination of the spinal white matter which was almost of devoid of myelin at P20
• the corpus callosum and the cerebellar white matter also showed a marked reduction of myelin
• but no obvious ultrastructural defects in the myelin architecture was found
|
behavior/neurological
|
• the motor performance on rotarod testing was markedly lower
|
|
• impaired control of hindlimb movements starting at 2 weeks of age
|
growth/size/body
|
• mutant mice lagged behind controls in weight gain
|
reproductive system
|
• overall breeding performance was poor
|
