Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palmtm1.2Kili mutation
(1 available);
any
Palm mutation
(26 available)
Tg(Ins2-VEGFC)#Pepr mutation
(0 available)
Tg(RIP1-Tag)2Dh mutation
(0 available)
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immune system
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• 12-week-old mice show a significant decrease in the Lyve-1+ lymphatic coverage of pancreatic tumors relative to double transgenic mice that are wild-type for Palm, indicating impaired tumor-associated lymphangiogenesis
• however, no changes in the number of pancreatic tumors, tumor volume, or intratumoral CD31+ blood microvessel density are observed relative to double transgenic mice wild-type for Palm
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palmtm1.2Kili mutation
(1 available);
any
Palm mutation
(26 available)
Tg(Ins2-VEGFC)#Pepr mutation
(0 available)
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|
|
immune system
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• 4-week-old mice show an increase in peri-insular lymphangiogenesis and Lyve-1+ lymphatic vessel density in the periphery of islets of Langerhans that is comparable to that seen in non-tumorigenic Tg(Ins2-VEGFC)#Pepr transgenic mice, consistent with de novo lymphangiogenesis
• however, no increase in CD31+ blood microvessel density is observed within islets, similar to Tg(Ins2-VEGFC)#Pepr mice, suggesting normal angiogenesis
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Analysis Tools