Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation
(0 available);
any
Gata1 mutation
(44 available)
Tg(HBB-cre)1Phi mutation
(0 available)
Tg(HBB-Gata1)G4Phi mutation
(0 available)
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mortality/aging
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• some mutant female embryos die by E13.5 - E14.0 and all are dead before birth similar to males hemizygous for Tg(HBB-Gata1)G4Phi
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hematopoietic system
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• definitive erythropoiesis is impaired with at least 2-fold more primitive cells compared to definitive cells present at E14.0
• compound mutant females are more severely affect compared to males hemizygous for Tg(HBB-Gata1)G4Phi and females heterozygous Gata1tm1Phi and hemizygous for Tg(HBB-cre)1Phi
• at E14.0, fewer cells beyond the polychromatic erythroblast stage are seen are seen in the liver and in hanging drop assays erythroid progenitors fail to differentiate
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• most surviving mutant female embryos are anemic at E13.5 - E14.0 similar to males hemizygous for Tg(HBB-Gata1)G4Phi
• at E13.5, about 4% of the total circulating blood cells are immature erythroid precursors
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation
(0 available);
any
Gata1 mutation
(44 available)
Tg(HBB-Gata1)G4Phi mutation
(0 available)
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hematopoietic system
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• the onset of definitive erythropoiesis is delayed with a lower ratio of definitive to primitive erythroid cells at E13.5 and E14.0
• differentiation of erythroid progenitors in the hanging drop assay is intermediate between wild-type mice and males hemizygous for Tg(HBB-Gata1)G4Phi
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• hemizygous male embryos die by E14.5
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hematopoietic system
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• at E13.5, the number of enucleated to nucleated erythrocytes is reduced more than 3-fold compared to wild-type males and more early basophilic erythoid precursors suggesting impairment of definitive erythropoiesis
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• hemizygous male embryos are anemic at E12.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• some hemizygous male embryos die by E13.5 - E14.0 and all are dead before birth
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hematopoietic system
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• definitive erythropoiesis is impaired
• at E14.0, fewer erythroid cells in late in the differentiation process are seen in the liver and in hanging drop assays erythroid progenitors fail to differentiate
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• most surviving hemizygous male embryos are anemic at E13.5 - E14.0 with about 7-fold fewer cells in the blood
• at E13.5, about 2% of the total circulating blood cells are immature erythroid precursors
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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normal phenotype
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• hemizygous females are viable with normal definitive erythropoiesis
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Analysis Tools