Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
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normal phenotype
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• homozygous null mice develop normally and exhibit normal testicular morphology, spermatogenesis and fertility, although Hist1h1a (H1.1), Hist1h1c (H1.2) and Hist1h1e (H1.4) gene expression was enhanced during spermatogenesis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
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cellular
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice
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reproductive system
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice
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• produced no offspring when mated to wild-type females
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• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
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• impaired sperm penetration of zona pellucida from wild-type females
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
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reproductive system
N |
• male fertility is normal
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
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reproductive system
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• fertility of males is reduced to 20%-50% of controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
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reproductive system
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• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
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• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
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• litter size was sharply reduced when mutant males were mated to wild-type females
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• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
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• reduced binding of sperm to zona pellucida from wild-type females
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cellular
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• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
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• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
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