All Phenotypes Tnf<tm2Jods> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnf^tm2Jods/Tnf^tm2Jods	C57BL/6-Tnf^tm2Jods	MGI:3582931
hm2	Tnf^tm2Jods/Tnf^tm2Jods	involves: C57BL/6	MGI:3582923
hm3	Tnf^tm2Jods/Tnf^tm2Jods	involves: C57BL/6 * C57BL/6J	MGI:4867651

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal spleen white pulp morphology ( J:98591 )

• some loss of B and T cell area segregation, however less than seen in homozygous Tnf^tm1Jods mice

abnormal metallophilic macrophage morphology ( J:98591 )

• the MOMA-1⁺ marginal zone metallophilic macrophages did not form a completely continuous cell layer

abnormal spleen follicular dendritic cell network ( J:98591 )

• follicular dendritic cell networks were undetectable in unimmunized homozygous mutant mice

• size and frequency of the formation CR1⁺ follicular dendritic networks upon immunization was substantially less than in wild-type

abnormal spleen primary B follicle morphology ( J:98591 )

• absent primary B cell follicles

decreased spleen germinal center number ( J:98591 )

• frequency of the formation of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

decreased spleen germinal center size ( J:98591 )

• size of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

abnormal Peyer's patch follicle morphology ( J:98591 )

• imperfect primary B cell follicles, however separation of T and B cell regions was fairly normal

abnormal lymph node primary follicle morphology ( J:98591 )

abnormal immune system physiology ( J:98591 )

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:98591 )

• reduced severity of experimental autoimmune encephalomyelitis (EAE) under suboptimal immunization conditions relative to wild-type, with less inflammation in the spinal cord and the majority of homozygous mutant mice recovering rapidly

decreased susceptibility to endotoxin shock ( J:98591 )

• resistant to endotoxic shock induced by low doses of LPS, however at high doses, started to show signs of shock and 2/5 mice succumbed to shock, however with a delayed time of death compared to wild-type

hematopoietic system

abnormal spleen white pulp morphology ( J:98591 )

• some loss of B and T cell area segregation, however less than seen in homozygous Tnf^tm1Jods mice

abnormal metallophilic macrophage morphology ( J:98591 )

• the MOMA-1⁺ marginal zone metallophilic macrophages did not form a completely continuous cell layer

abnormal spleen follicular dendritic cell network ( J:98591 )

• follicular dendritic cell networks were undetectable in unimmunized homozygous mutant mice

• size and frequency of the formation CR1⁺ follicular dendritic networks upon immunization was substantially less than in wild-type

abnormal spleen primary B follicle morphology ( J:98591 )

• absent primary B cell follicles

decreased spleen germinal center number ( J:98591 )

• frequency of the formation of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

decreased spleen germinal center size ( J:98591 )

• size of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

Allelic Composition	Tnf^tm2Jods/Tnf^tm2Jods
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnf^tm2Jods mutation (1 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:127028 )

• mutants control parasite replication as effectively as infected wild-type C57Bl/6 60 days following infection with L.major

• neutrophil numbers are similar in uninfected or infected (during first days of infection) wild-type controls and Tnf-null mice; levels after 7 days are similar to infected controls

• lymph node cells secrete similar levels of IFN-gamma to cells from infected wild-type; upon L. major re-stimulation, similar levels of Il-4 are released

• number of parasitized neutrophils in lesion is similar to infected controls at 4 hours after i.p. injection of L. major; percentage of proliferating parasites released from neutrophils is similar to infected controls

decreased immunoglobulin level ( J:127028 )

• levels of IgG2a in sera are lower than in infected wild-type controls

abnormal lymph node cell ratio ( J:127028 )

• number of IFN-gamma secreting CD4+ T cells is slightly but significantly increased in draining lymph nodes compared to infected wild-type C57BL/6

increased susceptibility to bacterial infection ( J:98170 )

• initially, were able to contain M. tuberculosis growth to a similar extent as wild-type, however were unable to control infection long term (after about 12 weeks), showed more diffuse lesions and increased neurtrophil infiltrate than in wild-type and had a mean time of death at 170 days

hematopoietic system

decreased immunoglobulin level ( J:127028 )

• levels of IgG2a in sera are lower than in infected wild-type controls

Allelic Composition	Tnf^tm2Jods/Tnf^tm2Jods
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnf^tm2Jods mutation (1 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver free fatty acids level ( J:112797 )

• when fed a high cholesterol diet

liver/biliary system

decreased liver free fatty acids level ( J:112797 )

• when fed a high cholesterol diet

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