About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mfge8Gt(KST227)Byg
gene trap KST227, BayGenomics
MGI:3578644
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg B6.129P2-Mfge8Gt(KST227)Byg MGI:3578949
hm2
Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3623586


Genotype
MGI:3578949
hm1
Allelic
Composition
Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic
Background
B6.129P2-Mfge8Gt(KST227)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8Gt(KST227)Byg mutation (3 available); any Mfge8 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

immune system
• apoptotic cell phagocytosis by macrophages is reduced
• the spleen is enlarged and apoptotic cells accumulate in the spleen

cardiovascular system
• in a surgically induced ischemic hindlimb model VEGFA treatment does not stimulate neovessel formation in mutants unlike in wild-type mice; however FGF2 treatment stimulates neovessel formation in both mutant and wild-type mice
• neovascularization of implanted matrigel is reduced in VEGFA-treated homozygotes compared to wild-type mice; however, embryonic vascular development is normal

renal/urinary system
• in aging homozygotes, immunoglobulin deposits are seen in the kidney

hematopoietic system
• apoptotic cell phagocytosis by macrophages is reduced
• the spleen is enlarged and apoptotic cells accumulate in the spleen

growth/size/body
• the spleen is enlarged and apoptotic cells accumulate in the spleen

cellular
• apoptotic cell phagocytosis by macrophages is reduced




Genotype
MGI:3623586
hm2
Allelic
Composition
Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8Gt(KST227)Byg mutation (3 available); any Mfge8 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

immune system
• impaired engulfment of apoptotic thymocytes
• inflammation of the mammary glands is seen by day 4 of involution
• age dependent splenomegaly

hematopoietic system
• impaired engulfment of apoptotic thymocytes
• age dependent splenomegaly

endocrine/exocrine glands
• on the first and second days of involution increased apoptotic bodies are seen in the alveolar lumens and alveolar collapse and fat cell repopulation are delayed; however no increase in the number of apoptotic cells in the epithelium is seen
• engulfment of apoptotic cells by alveolar epithelial cells is reduced
• at 4 weeks of age ducts appear normal but by 8 weeks dilation and distension of the ducts is seen in some homozygotes
• progressive ductal dilation of the primary, secondary, and tertiary ducts is seen with repeated pregnancies; however duct diameter is similar to wild-type in 9 month old virgin mice
• inflammation of the mammary glands is seen by day 4 of involution

integument
• on the first and second days of involution increased apoptotic bodies are seen in the alveolar lumens and alveolar collapse and fat cell repopulation are delayed; however no increase in the number of apoptotic cells in the epithelium is seen
• engulfment of apoptotic cells by alveolar epithelial cells is reduced
• at 4 weeks of age ducts appear normal but by 8 weeks dilation and distension of the ducts is seen in some homozygotes
• progressive ductal dilation of the primary, secondary, and tertiary ducts is seen with repeated pregnancies; however duct diameter is similar to wild-type in 9 month old virgin mice
• inflammation of the mammary glands is seen by day 4 of involution

growth/size/body
• age dependent splenomegaly

cellular
• impaired engulfment of apoptotic thymocytes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/30/2024
MGI 6.23
The Jackson Laboratory