Analysis Tools
mortality/aging
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• embryos begin to die at E11.5 and no live embryos are seen after E14.5
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• embryos begin to die at E11.5 and no live embryos are seen after E14.5
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hematopoietic system
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• the number of hematopoeitic stem cells is reduced to a greater extent than any of the hematopoeitic cell lineages in the fetal liver at E12.5
• at E12.5, the ability of fetal liver cells to form erythroid, myeloid, or mixed colonies is reduced
• at E10.5, the ability of cells from the yolk sac and aorta-gonad-mesonephros to form erythroid, myeloid, or mixed colonies is reduced, although the ability to form myeloid colonies is not as severely affected as in fetal liver cells
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• all hematopoietic cell lineage numbers are reduced in the fetal liver at E12.5
• hematopoietic clusters in the aorta, vitelline, and umbilical arteries are fewer in number and reduced in size
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• circulating megakaryoblasts are virtually undetectable
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cardiovascular system
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• at E11.5 and E12.5, in the mesenchymal region large vascular sinuses are seen rather than the normal capillary network
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hemorrhage
(
J:98307
)
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• at E11.5, hemorrhages appear in the neural tube lumen and at E12.5 hemorrhages are also seen in the dorsal trunk regions
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liver/biliary system
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• at E12.5 the liver is about 50% smaller and all hematopoeitic cell lineage numbers are reduced
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integument
