All Phenotypes Ift122<sopb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ift122^sopb
sister of open brain
MGI:3578529

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ift122^sopb/Ift122^sopb	C3Fe.B6-Ift122^sopb	MGI:4888263
hm2	Ift122^sopb/Ift122^sopb	involves: C3HeB/FeJ * C57BL/6J	MGI:3580674
cx3	Ift122^sopb/Ift122^sopb Shh^tm1Chg/Shh^tm1Chg	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:4888266
cx4	Gli2^tm1Alj/Gli2^tm1Alj Ift122^sopb/Ift122^sopb	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:4888267
cx5	Ift122^sopb/Ift122^sopb Kif3a^tm1Gsn/Kif3a^tm1Gsn	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:4888268
cx6	Ift122^sopb/Ift122^sopb Smo^tm1Amc/Smo^tm1Amc	involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J	MGI:4888269

Allelic Composition	Ift122^sopb/Ift122^sopb
Genetic Background	C3Fe.B6-Ift122^sopb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift122^sopb mutation (0 available); any Ift122 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:168317 )

• die around E13.5

embryo

abnormal motile primary cilium morphology ( J:168317 )

• swollen

enlarged pharyngeal arch ( J:168317 )

abnormal left-right axis patterning ( J:168317 )

abnormal neural tube morphology ( J:168317 )

• at E10.5 the neural tube shows a ventralized phenotype at the level of the hindlimbs

• at the lumbar and brachial levels the cilia are swollen at the distal ends

open neural tube ( J:168317 )

• open caudal neural tube

vision/eye

abnormal eye morphology ( J:168317 )

• eye defects

limbs/digits/tail

preaxial polydactyly ( J:168317 )

cardiovascular system

abnormal direction of heart looping ( J:168317 )

• randomized

cellular

abnormal cilium morphology ( J:168317 )

• cilia frequency is somewhat reduced on primary MEFs

abnormal motile primary cilium morphology ( J:168317 )

• swollen

craniofacial

enlarged pharyngeal arch ( J:168317 )

nervous system

abnormal neural tube morphology ( J:168317 )

• at E10.5 the neural tube shows a ventralized phenotype at the level of the hindlimbs

• at the lumbar and brachial levels the cilia are swollen at the distal ends

open neural tube ( J:168317 )

• open caudal neural tube

exencephaly ( J:168317 )

Allelic Composition	Ift122^sopb/Ift122^sopb
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift122^sopb mutation (0 available); any Ift122 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E13-E14

nervous system

exencephaly ( J:98216 )

abnormal spinal cord morphology ( J:98216 )

• ventralized caudal spinal cord

limbs/digits/tail

polydactyly ( J:98216 )

Allelic Composition	Ift122^sopb/Ift122^sopb Shh^tm1Chg/Shh^tm1Chg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift122^sopb mutation (0 available); any Ift122 mutation (52 available)
Shh^tm1Chg mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:168317 )

• at E10.5 the neural tube is ventralized similar to the phenotype in mice homozygous for Ift122^sopb alone

open neural tube ( J:168317 )

nervous system

abnormal neural tube morphology ( J:168317 )

• at E10.5 the neural tube is ventralized similar to the phenotype in mice homozygous for Ift122^sopb alone

open neural tube ( J:168317 )

exencephaly ( J:168317 )

Allelic Composition	Gli2^tm1Alj/Gli2^tm1Alj Ift122^sopb/Ift122^sopb
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Ift122^sopb mutation (0 available); any Ift122 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:168317 )

• patterning resembles that in mice homozygous for Gli2^tm1Alj alone

nervous system

abnormal neural tube morphology ( J:168317 )

• patterning resembles that in mice homozygous for Gli2^tm1Alj alone

Allelic Composition	Ift122^sopb/Ift122^sopb Kif3a^tm1Gsn/Kif3a^tm1Gsn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift122^sopb mutation (0 available); any Ift122 mutation (52 available)
Kif3a^tm1Gsn mutation (1 available); any Kif3a mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent embryonic cilia ( J:168317 )

• lack primary cilia and resemble mice homozygous for Kif3a^tm1Gsn alone

abnormal neural tube morphology ( J:168317 )

• patterning resembles that in mice homozygous for Kif3a^tm1Gsn alone

nervous system

abnormal neural tube morphology ( J:168317 )

• patterning resembles that in mice homozygous for Kif3a^tm1Gsn alone

cellular

absent embryonic cilia ( J:168317 )

• lack primary cilia and resemble mice homozygous for Kif3a^tm1Gsn alone

Allelic Composition	Ift122^sopb/Ift122^sopb Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift122^sopb mutation (0 available); any Ift122 mutation (52 available)
Smo^tm1Amc mutation (1 available); any Smo mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:168317 )

• patterning resembles that in mice homozygous for Ift122^sopb alone

nervous system

abnormal neural tube morphology ( J:168317 )

• patterning resembles that in mice homozygous for Ift122^sopb alone

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