Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l5lulu mutation
(0 available);
any
Epb41l5 mutation
(46 available)
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mortality/aging
embryo
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• deficit of axial mesoderm
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• deficit of paraxial mesoderm
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l5lulu mutation
(0 available);
any
Epb41l5 mutation
(46 available)
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mortality/aging
embryo
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• endoderm is normally specified, but fails to move ventrally to form the gut tube
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• by E7.75, anterior mesodermal wings of mesoderm layer around embryo circumference are only one cell layer thick compared to 3-4 layers in wild-type embryos
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• at E8.5, embryos have shortened trunks
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• embryos arrest at E8.5-9
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• at E8.5, anterior neural plate is broad, open, and folded into irregular ridges, and thicker than in wild-type
• nuclei of neural plate cells are more spherical than wild-type nuclei, while mutant cells with ellipsoid nuclei do not align their long axes with apical-basal axis of plate
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• neural plates fail to close to form neural tube
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• organization shows abnormalities, with 20% of mitotic nuclei in mutant neuroepithelium located away from apical surface compared to only 5% in wild-type
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• epithelial-mesenchymal transition at primitive streak is defective; at E8.5, some cells have delaminated from the epithelial layer and are located in an abnormal bulge above Tbx6-expressing mesoderm
• primitive streak at E7.75 is thicker and wider than in wild-type embryos; increase in thickness is apparent at E8.5 also
• at E7.5, actin organization in primitive streak is defective, with absence of circumferential F-actin, and prominent puncta of F-actin in cells accumulating in streak at E7.5 and 8.5
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• embryos lack visible somites at E8.5
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• yolk sac appears ruffled at E8.5
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• allantois fails to fuse with chorion
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nervous system
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• at E8.5, anterior neural plate is broad, open, and folded into irregular ridges, and thicker than in wild-type
• nuclei of neural plate cells are more spherical than wild-type nuclei, while mutant cells with ellipsoid nuclei do not align their long axes with apical-basal axis of plate
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• neural plates fail to close to form neural tube
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• organization shows abnormalities, with 20% of mitotic nuclei in mutant neuroepithelium located away from apical surface compared to only 5% in wild-type
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cardiovascular system
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• lateral anlage does not move to embryo midline to form a single heart tube
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cellular
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• nuclei of neural plate cells are rounder with width: length ratio of 1.44 compared to the elongated and ellipsoid wild-type nuclei that have average width:length ratio of 2.33
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l5Gt(XC282)Byg mutation
(0 available);
any
Epb41l5 mutation
(46 available)
Epb41l5lulu mutation
(0 available);
any
Epb41l5 mutation
(46 available)
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mortality/aging
embryo
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• failure to complete turning
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• embryos form 10-12 pairs of abnormally shaped somites
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l5Gt(AE0088)Wtsi mutation
(0 available);
any
Epb41l5 mutation
(46 available)
Epb41l5lulu mutation
(0 available);
any
Epb41l5 mutation
(46 available)
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mortality/aging
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• embryos recapitulate Epb4.1l5lulu phenotype
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embryo
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• at E8.5, embryos have shortened trunks
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• at E8.5, anterior neural plate is broad, open, and folded into irregular ridges, and thicker than in wild-type
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• embryos lack visible somites at E8.5
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nervous system
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• at E8.5, anterior neural plate is broad, open, and folded into irregular ridges, and thicker than in wild-type
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Analysis Tools