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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crebbptm1Pkb
targeted mutation 1, Paul K Brindle
MGI:3578129
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crebbptm1Pkb/Crebbptm1Pkb involves: 129P2/OlaHsd * C57BL/6 MGI:3578234


Genotype
MGI:3578234
hm1
Allelic
Composition		 Crebbptm1Pkb/Crebbptm1Pkb
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Pkb mutation (2 available); any Crebbp mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:98329 )
• about 40% lethality before weaning due to unknown causes, survivors are viable

hematopoietic system
decreased thymocyte number ( J:98329 )
• slight reduction in numbers

growth/size/body
decreased body size ( J:98329 )
• body size was reduced at 4 weeks of age

immune system
decreased thymocyte number ( J:98329 )
• slight reduction in numbers

endocrine/exocrine glands
decreased thymocyte number ( J:98329 )
• slight reduction in numbers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory