Phenotypes associated with this allele
Allelic
Composition |
Plcg2Ali5/Plcg2Ali5
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Genetic
Background |
involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2Ali5 mutation
(0 available);
any
Plcg2 mutation
(74 available)
|
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immune system
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• reduction of transitional T2 B cells
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• reduction of mature B cells
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• 66% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype
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• approximately 90% of homozygous mice had severe inflammation of the paws
• they also developed severe keratitis
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• proliferative intra- and extracapillary glomerulonephritis in eight out of eight
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renal/urinary system
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• proliferative intra- and extracapillary glomerulonephritis in eight out of eight
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hematopoietic system
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• reduction of transitional T2 B cells
|
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• reduction of mature B cells
|
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• 66% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2Ali5 mutation
(0 available);
any
Plcg2 mutation
(74 available)
|
|
|
immune system
|
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• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number
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• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells
• anti-DNA antibodies were not detected
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• mice have normal paws at birth but gradually develop swollen and deformed
• male mice were affected earlier at 2 months than female at 8-10 months
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
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• in the superficial layers of the skin of the paws and ears
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skeleton
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
|
hematopoietic system
|
|
• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number
|
|
|
• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells
• anti-DNA antibodies were not detected
|
integument
|
|
• in the superficial layers of the skin of the paws and ears
|
Allelic
Composition |
Plcg2Ali5/Plcg2+
|
|
Genetic
Background |
involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2Ali5 mutation
(0 available);
any
Plcg2 mutation
(74 available)
|
|
|
immune system
|
N |
• no chronic inflammation of the paw was observed
|
|
|
• 28% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype
|
renal/urinary system
hematopoietic system
|
|
• 28% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.1Twin mutation
(0 available);
any
Igh mutation
(43 available)
Plcg2Ali5 mutation
(0 available);
any
Plcg2 mutation
(74 available)
|
|
|
immune system
|
N |
• the distribution of B cell subsets in the peritoneal cavity is normal
|
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• compared with Ightm1.1Twin homozygotes
|
hematopoietic system
|
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• compared with Ightm1.1Twin homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2Ali5 mutation
(0 available);
any
Plcg2 mutation
(74 available)
Rag1tm1Mom mutation
(49 available);
any
Rag1 mutation
(120 available)
|
|
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immune system
|
|
• approximately 70% of homozygous mice developed despite absence of B and T cells
|
|
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
|
|
|
• in the superficial layers of the skin of the paws and ears
|
skeleton
|
|
• resulting in severe arthritis of the small joints of the paws and missing phalanges
|
integument
|
|
• in the superficial layers of the skin of the paws and ears
|
Analysis Tools