Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rereeyes3 mutation
(0 available);
any
Rere mutation
(212 available)
|
|
|
Microphthalmia in Rereeyes3/Rereeyes3 mice
growth/size/body
|
• snouts described as narrower than controls
|
|
• slightly smaller than controls
|
|
• at 3, 7 and 10 weeks of age
|
craniofacial
|
• snouts described as narrower than controls
|
vision/eye
|
• unilateral or bilateral
(J:199403)
|
renal/urinary system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rereeyes3 mutation
(0 available);
any
Rere mutation
(212 available)
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
|
|
Cardiovascular malformations in Rereom/Rereeyes3 embryos on a C57BL6 background
mortality/aging
|
• on a B6 background, mice are reported to exhibit perinatal lethality with no pups recovered at P0
• however, fetuses are found at Mendelian ratios at E15.5
|
cardiovascular system
|
• Background Sensitivity: cardiovascular malformation in 6 of 6 mice on a congenic C57BL/6 background unlike mice on a mixed background
|
|
• in the myocardium of the ventricle wall of adult mice
|
renal/urinary system
craniofacial
|
• at E15.5, palate shelves fail to contact each other in the midline
|
|
• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice
|
digestive/alimentary system
|
• at E15.5, palate shelves fail to contact each other in the midline
|
|
• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice
|
growth/size/body
|
• at E15.5, palate shelves fail to contact each other in the midline
|
|
• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice
|
endocrine/exocrine glands
N |
• mice with renal agenesis exhibit normal adrenal glands
|
Allelic Composition |
Rereeyes3/Rereom
|
|
Genetic Background |
involves: 129S6/SvEvTac * BTBR * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rereeyes3 mutation
(0 available);
any
Rere mutation
(212 available)
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
|
|
Severe microphthalmia in Rereeyes3/Rereom mice
mortality/aging
|
• despite being born in Mendelian ratios, most mice die before weaning
|
nervous system
N |
• neuron proliferation, apoptosis and maturation of granule cells are normal
|
|
• reduced surface area of the cerebral hemispheres at E17.0 and P0
|
|
• decreased NeuN+ hippocampal neurons at E18.5 in the Ammon's horn
• however, the number of NeuN+ neurons in the dentate gyrus is normal
|
|
• reduced surface area of the cerebellum at E17.0 and P0
|
hearing/vestibular/ear
growth/size/body
|
• despite normal birth weight, mice weight less at P7 compared with wild-type mice
|
|
• body weights plateau at 6 weeks of age unlike wild-type mice
|
vision/eye
|
• unilateral or bilateral; more severe than in Rereeyes3 homozygotes
|
cardiovascular system
N |
• mice on a mixed background exhibit normal cardiovascular morphology unlike mice on a congenic C57BL/6 background
|