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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-Ppif)26.2Jmol
transgene insertion 26.2, Jeffery D Molkentin
MGI:3577401
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Myh6-Ppif)26.2Jmol/0 FVB/N-Tg(Myh6-Ppif)26.2Jmol MGI:3577402


Genotype
MGI:3577402
tg1
Allelic
Composition		 Tg(Myh6-Ppif)26.2Jmol/0
Genetic
Background		 FVB/N-Tg(Myh6-Ppif)26.2Jmol
Find Mice Using the International Mouse Strain Resource (IMSR)
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber mitochondrial morphology ( J:97660 )
• this transgene only affects mitochondria in the heart
• mitochondrial architecture but not numbers was affected

cellular
abnormal myocardial fiber mitochondrial morphology ( J:97660 )
• this transgene only affects mitochondria in the heart
• mitochondrial architecture but not numbers was affected
abnormal mitochondrial crista morphology ( J:97660 )
• loss of cristae was seen at 2 months of age
dilated mitochondrion ( J:97660 )
• mitochondrial swelling was seen at 2 months of age
increased apoptosis ( J:97660 )
• in the heart

muscle
abnormal myocardial fiber mitochondrial morphology ( J:97660 )
• this transgene only affects mitochondria in the heart
• mitochondrial architecture but not numbers was affected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory