Phenotypes associated with this allele

• Allele Symbol: Ppif^tm1Jmol
• Allele Name: targeted mutation 1, Jeffery D Molkentin
• Allele ID: MGI:3577093
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppif^tm1Jmol/Ppif^tm1Jmol	involves: 129	MGI:3577395
cn2	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Ppif^tm1Jmol/Ppif^tm1Jmol Slc8b1^tm1c(EUCOMM)Wtsi/Slc8b1^tm1c(EUCOMM)Wtsi	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:7316565

Genotype
MGI:3577395

hm1

• Allelic Composition: Ppif^tm1Jmol/Ppif^tm1Jmol
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:97660 )

• resistant to swelling and permeability transition induced by lower calcium ion levels

• greater capacity for calcium uptake

cardiovascular system

decreased myocardial infarct size ( J:97660 )

• 40% reduction in infarction area when subjected to cardiac ischemia/reperfusion injury

homeostasis/metabolism

decreased myocardial infarct size ( J:97660 )

• 40% reduction in infarction area when subjected to cardiac ischemia/reperfusion injury

Genotype
MGI:7316565

cn2

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Ppif^tm1Jmol/Ppif^tm1Jmol; Slc8b1^{tm1c(EUCOMM)Wtsi}/Slc8b1^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

cardiovascular system

cardiac hypertrophy ( J:325413 )

• near complete rescue in tamoxifen-treated mice

decreased ventricle muscle contractility ( J:325413 )

• near complete rescue in tamoxifen-treated mice

growth/size/body

cardiac hypertrophy ( J:325413 )

• near complete rescue in tamoxifen-treated mice

muscle

decreased ventricle muscle contractility ( J:325413 )

• near complete rescue in tamoxifen-treated mice

abnormal sarcomere morphology ( J:325413 )

• disorganization is nearly completely rescued in tamoxifen-treated mice