Phenotypes associated with this allele

• Allele Symbol: Smurf1^tm1Yez
• Allele Name: targeted mutation 1, Ying E Zhang
• Allele ID: MGI:3576775
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smurf1^tm1Yez/Smurf1^tm1Yez	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)	MGI:3577518

Genotype
MGI:3577518

hm1

• Allelic Composition: Smurf1^tm1Yez/Smurf1^tm1Yez
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal osteoblast physiology ( J:97303 )

• osteoblast function is increased without any change in osteoblast numbers or in the number or function of the osteoclasts

• bone extra cellular matrix production is increased

skeleton

abnormal osteoblast physiology ( J:97303 )

• osteoblast function is increased without any change in osteoblast numbers or in the number or function of the osteoclasts

• bone extra cellular matrix production is increased

increased bone mineral density of femur ( J:97303 )

• increased bone mineral density seen in the shaft of the femur

increased compact bone thickness ( J:97303 )

• thickening of the cortical bone of the shaft is seen in more than 75% of long bones

increased trabecular bone mass ( J:97303 )

• trabecular bone in the femur is slightly increased at 4 months and more dramatically increased at 9 months of age; however the length and structure of the growth plates were normal