All Phenotypes Spgl MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spgl
spag luxate
MGI:3576619

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spgl/Spgl	involves: BALB/cAnNCrl * C3H/He	MGI:5544753
ht2	Spgl/Spgl⁺	involves: BALB/cAnNCrl * C3H/He	MGI:5544744
ht3	Spgl/Spgl⁺	involves: BALB/cAnNCrl * C3H/He * C57BL/6	MGI:5544748
ht4	Spgl/Spgl⁺	involves: BALB/cAnNCrl * C3H/He * M. m. castaneus	MGI:5544752

Allelic Composition	Spgl/Spgl
Genetic Background	involves: BALB/cAnNCrl * C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spgl mutation (2 available); any Spgl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:169366 )

• craniofacial defects are sometimes present (not fully penetrant)

limbs/digits/tail

polydactyly ( J:169366 )

• non-mirror-image polydactyly of the hindlimbs accompanied by mirror-image polydactyly of the forelimbs

absent tibia ( J:169366 )

• tibiae are greatly reduced or absent, resulting in a rotational defect of the hindlimbs

hemimelia ( J:169366 )

• tibiae are greatly reduced or absent, resulting in a rotational defect of the hindlimbs

reproductive system

reproductive system phenotype ( J:169366 )

N	• homozygous mutant mice of both sexes are fertile

skeleton

absent tibia ( J:169366 )

• tibiae are greatly reduced or absent, resulting in a rotational defect of the hindlimbs

Allelic Composition	Spgl/Spgl⁺
Genetic Background	involves: BALB/cAnNCrl * C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spgl mutation (2 available); any Spgl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:169366 )

• mirror-image polydactyly of both hindlimbs; forelimbs are unaffected

• Background Sensitivity: on this genetic background, the limb phenotype is highly penetrant

reproductive system

reproductive system phenotype ( J:169366 )

N	• heterozygous mutant mice of both sexes are fertile

Allelic Composition	Spgl/Spgl⁺
Genetic Background	involves: BALB/cAnNCrl * C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spgl mutation (2 available); any Spgl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:169366 )

• mirror-image polydactyly of both hindlimbs; forelimbs are unaffected

• Background Sensitivity: on this genetic background, the limb phenotype is highly penetrant

Allelic Composition	Spgl/Spgl⁺
Genetic Background	involves: BALB/cAnNCrl * C3H/He * M. m. castaneus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spgl mutation (2 available); any Spgl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:169366 )

N	• when mutant mice are outcrossed to M. m. castaneus mice, no pups with limb abnormalities are observed, suggesting low or no penetrance of the limb phenotype in this background

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