Phenotypes associated with this allele

• Allele Symbol: Fxyd1^tm1Atck
• Allele Name: targeted mutation 1, Amy L Tucker
• Allele ID: MGI:3576231
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fxyd1^tm1Atck/Fxyd1^tm1Atck	involves: 129S7/SvEvBrd * C57BL/6	MGI:3576733

Genotype
MGI:3576733

hm1

• Allelic Composition: Fxyd1^tm1Atck/Fxyd1^tm1Atck
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:97365 )

• the cardiac mass-to-tibial length ratio were larger than wild-type

cardiac hypertrophy ( J:97365 )

• larger cardiomyocytes

abnormal cardiovascular system physiology ( J:97365 )

• in in vitro assay, sarcolemma-enriched membrane fraction from the mutant, total Na-K-ATPase activity was 50% lower

increased cardiac muscle contractility ( J:97365 )

• higher ejection fractions by cardiac MRI analysis in 5 month old mice

muscle

increased cardiac muscle contractility ( J:97365 )

• higher ejection fractions by cardiac MRI analysis in 5 month old mice

growth/size/body

increased heart weight ( J:97365 )

• the cardiac mass-to-tibial length ratio were larger than wild-type

cardiac hypertrophy ( J:97365 )

• larger cardiomyocytes