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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppp1r13lwa3
waved 3
MGI:3575541
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ppp1r13lwa3/Ppp1r13lwa3 either: C57BL/6-Ppp1r13lwa3 or (involves: C57BL/6 * DBA/2J) MGI:3575691


Genotype
MGI:3575691
hm1
Allelic
Composition
Ppp1r13lwa3/Ppp1r13lwa3
Genetic
Background
either: C57BL/6-Ppp1r13lwa3 or (involves: C57BL/6 * DBA/2J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r13lwa3 mutation (0 available); any Ppp1r13l mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• at birth on the ventricles of the heart, lesions are seen that consist of focal areas of myofiber degeneration, necrosis, and mineralization
• these lesions first appear on the anterior aspect of the right ventricle near the outflow tract and become larger with age
• extensive necrosis of the anterior free wall and septum are seen by P14

mortality/aging
• surviving female homozygotes often die suddenly during the post-partum period
• Background Sensitivity: postnatal viability is reduced on the C57BL/6 background compared to the mixed C57BL/6 DBA/2J background
• fewer than 10% of homozygotes survive beyond 4 weeks of age

cardiovascular system
• at birth on the ventricles of the heart, lesions are seen that consist of focal areas of myofiber degeneration, necrosis, and mineralization
• these lesions first appear on the anterior aspect of the right ventricle near the outflow tract and become larger with age
• extensive necrosis of the anterior free wall and septum are seen by P14
• seen in 8 week old homozygotes characterized by left ventricular chamber dilation, left atrial enlargement and reduction in contractile function without left ventricular hypertrophy
• at 8 weeks of age, fractional shortening is reduced to 24 +/- 14% in homozygotes compared to 53 +/- 6% in wild-type mice

growth/size/body
• by 2 weeks of age homozygotes are about 60% the weight of normal littermates despite having similar birth weights

muscle
• at birth on the ventricles of the heart, lesions are seen that consist of focal areas of myofiber degeneration, necrosis, and mineralization
• these lesions first appear on the anterior aspect of the right ventricle near the outflow tract and become larger with age
• extensive necrosis of the anterior free wall and septum are seen by P14
• seen in 8 week old homozygotes characterized by left ventricular chamber dilation, left atrial enlargement and reduction in contractile function without left ventricular hypertrophy
• at 8 weeks of age, fractional shortening is reduced to 24 +/- 14% in homozygotes compared to 53 +/- 6% in wild-type mice

vision/eye

homeostasis/metabolism
• coronary artery thomboses are occasionally seen proximal to cardiomyocyte degeneration

integument
• the hair shaft is thinner but has normal length
• hair cuticles are normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory