Analysis Tools
normal phenotype
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• homozygous mice were healthy and fertile
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Allele Symbol Allele Name Allele ID |
Brsk2tm1Jrs targeted mutation 1, Joshua R Sanes MGI:3575113 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous mice were healthy and fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• died within 2 hours of birth
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• were only weakly responsive to tactile stimulation
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• showed little spontaneous movement
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• segregation of neuronal subtypes to sublayers within the cortical plate was disordered
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• the subplate was poorly defined
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• forebrain was noticeably smaller
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• the cerebral ventricle was enlarged at E19
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• neurons from the hippocampus grown in culture failed to form distinct axons and dendrites and exhibited polarization defects, showing neurites that were relatively uniform in length and branching complexity
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• cortex was abnormally thin at E19 however it contained the main cortical cell types
• increased apoptosis in the cerebral cortex
• cortical neurons did not extend long axons from the cortex to the thalamus and TAG-1+ corticothalamic axons were absent in mutants
• neurons from the cortex grown in culture failed to form distinct axons and dendrites and exhibited polarization defects, showing neurites that were relatively uniform in length and branching complexity
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• neurons often had a starburst morphology or processes that ran diagonally or tangentially rather than radially, and axons were difficult to distinguish from dendrites
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• cortical neurons did not extend long axons from the cortex to the thalamus and TAG-1+ corticothalamic axons were absent in mutants
• neurons from the cerebral cortex and the hippocampus grown in culture failed to form distinct axons and dendrites
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• cortical neurons did not extend long axons from the cortex to the thalamus and TAG-1+ corticothalamic axons were absent in mutants
• neurons from the cerebral cortex and the hippocampus grown in culture failed to form distinct axons and dendrites
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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