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Allele Symbol Allele Name Allele ID |
Foxp3tm2Ayr targeted mutation 2, Alexander Y Rudensky MGI:3574964 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• homozygous females have normal amounts of all major lymphoid populations including T cells and thymocytes and CD4+Cd25+ T cells
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• homozygous females are healthy
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced suppression of wild-type naive CD4+ T cells when compared with wild-type Treg cells
• TGFbeta induced Foxp3-expressing Treg, iTreg, cells have a reduced ability to inhibit the proliferation of nave CD4+ T cells
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• reduced suppression of wild-type naive CD4+ T cells when compared with wild-type Treg cells
• TGFbeta induced Foxp3-expressing Treg, iTreg, cells have a reduced ability to inhibit the proliferation of nave CD4+ T cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal positive selection and thymus and spleen cellularity
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• defects in thymocyte differentiation
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• reduced frequency of post-selection CD69+ double positive thymocytes
• however, the percent of CD4+CD8+ double positive thymocytes is normal
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• reduced percent in the percent spleen
• however, the percent in the thymus is normal
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• increased percent of Foxp3GFP within CD4+ T cells in the blood by 5 to 6 weeks
• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes
• reduced splenic regulatory T cell numbers that is not as severe as in the thymus indicating partial rebound
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• CD4+ T cells exhibit mild impairment calcium signaling with reduced duration of elevated intracellular calcium compared with wild-type cells
• however, peak intracellular calcium level is not reduced
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• reduced percent in the percent thymus spleen
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• defects in thymocyte differentiation
|
|
• reduced frequency of post-selection CD69+ double positive thymocytes
• however, the percent of CD4+CD8+ double positive thymocytes is normal
|
|
• reduced percent in the percent spleen
• however, the percent in the thymus is normal
|
|
• increased percent of Foxp3GFP within CD4+ T cells in the blood by 5 to 6 weeks
• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes
• reduced splenic regulatory T cell numbers that is not as severe as in the thymus indicating partial rebound
|
|
• CD4+ T cells exhibit mild impairment calcium signaling with reduced duration of elevated intracellular calcium compared with wild-type cells
• however, peak intracellular calcium level is not reduced
|
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• reduced percent in the percent thymus spleen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• hemizygous males have normal amounts of all major lymphoid populations including T cells and thymocytes and CD4+Cd25+ T cells
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• hemizygous males are healthy
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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