Analysis Tools
hematopoietic system
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• a 2-fold decrease in the number of multipotent and oligopotent progenitor cells in the G2/M phase of the cell cycle compared to wild-type cells; however, this did not correspond to an increase in apoptosis
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• a 3-fold decrease in the number of common myeloid progenitors and a 3- to 5-fold decrease in the ability of these cells to generate clonogenic myeloid colonies are seen
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• a 1.6-fold increase in the frequency of erythroid colony forming units is seen compared to wild-type littermates
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• a 1.3- and 1.5-fold increase in the frequency of macrophage and pre-B colony forming units, respectively, are seen compared to wild-type littermates
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• a 1.6-fold decrease in the number of common lymphoid progenitor cells but a 3-fold increase in the ability of these cells to generate pre-B colony forming units is seen
• however, the number of total thymocytes and CD3+ thymocytes are normal
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• hemizygous males have a 10% increase in the red blood cell count
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• mean cell volume is decreased
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immune system
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• a 1.3- and 1.5-fold increase in the frequency of macrophage and pre-B colony forming units, respectively, are seen compared to wild-type littermates
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