Phenotypes associated with this allele

• Allele Symbol: Eef1e1^{Gt(OST377244)Lex}
• Allele Name: gene trap OST377244, Lexicon Genetics
• Allele ID: MGI:3574590
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eef1e1^Gt(OST377244)Lex/Eef1e1^Gt(OST377244)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3576228
ht2	Eef1e1^Gt(OST377244)Lex/Eef1e1^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:3576229

Genotype
MGI:3576228

hm1

• Allelic Composition: Eef1e1^{Gt(OST377244)Lex}/Eef1e1^{Gt(OST377244)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:96923 )

• among the total of 83 embryos isolated from 7.5 to 9.5 days, only one homozygous embryo was found on E8.5

Genotype
MGI:3576229

ht2

• Allelic Composition: Eef1e1^{Gt(OST377244)Lex}/Eef1e1⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:96923 )

• the heterozygous mice were born at a ratio similar to the wild-type littermates indicating that about 50% of the heterozygous mice die prenatally

neoplasm

increased malignant tumor incidence ( J:96923 )

• the heterozygous mice developed different type of tumors including adenocarcinomas, sarcoma, hepatocarcinoma, and lymphomas by 15 months

cellular

abnormal cell cycle ( J:96923 )

• splenocyte from heterozygous mice showed a faster cell cycle than the wild-type cells

decreased splenocyte apoptosis ( J:96923 )

• splenocytes from heterozygous mice showed resistance to adriamycin-induced apoptosis

increased cell proliferation ( J:96923 )

• thymocytes, MEF cell isolated from heterozygous mice grew faster

• increased number of proliferative cells were detected in various tissues

increased splenocyte proliferation ( J:96923 )

• splenocytes isolated from heterozygous mice grew faster

hematopoietic system

decreased splenocyte apoptosis ( J:96923 )

• splenocytes from heterozygous mice showed resistance to adriamycin-induced apoptosis

increased splenocyte proliferation ( J:96923 )

• splenocytes isolated from heterozygous mice grew faster

immune system

decreased splenocyte apoptosis ( J:96923 )

• splenocytes from heterozygous mice showed resistance to adriamycin-induced apoptosis

increased splenocyte proliferation ( J:96923 )

• splenocytes isolated from heterozygous mice grew faster