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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cecr2Gt(pGT1)1Hemc
gene trap 1, Heather E McDermid
MGI:3574034
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc 129P2(C)-Cecr2Gt(pGT1)1Hemc MGI:3574278
hm2
 		Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc C.129P2-Cecr2Gt(pGT1)1Hemc MGI:3574277
hm3
 		Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc MGI:3574279
hm4
 		Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: 129P2/OlaHsd * BALB/c MGI:3574274
hm5
 		Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: 129P2/OlaHsd * BALB/c * FVB/N MGI:3574276
hm6
 		Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc MGI:3574280
ht7
 		Cecr2Gt(pGT1)1Hemc/Cecr2+ C.129P2-Cecr2Gt(pGT1)1Hemc MGI:5297953
ht8
 		Cecr2Gt(pGT1)1Hemc/Cecr2+ involves: 129P2/OlaHsd * BALB/c MGI:3574275


Genotype
MGI:3574278
hm1
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background		 129P2(C)-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:96325 )
• 63% penetrance of exencephaly

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
anencephaly DOID:0060668 OMIM:206500
 J:96325




Genotype
MGI:3574277
hm2
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background		 C.129P2-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:177709 )
• increased cranial neural tube width
exencephaly ( J:96325 , J:177709 )
• 74% penetrance of exencephaly (J:96325)
• penetrance is 74% at N6 and 69% at greater than N10 (J:177709)

embryo
abnormal neural tube morphology ( J:177709 )
• increased cranial neural tube width

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
anencephaly DOID:0060668 OMIM:206500
 J:96325




Genotype
MGI:3574279
hm3
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background		 FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:96325 )
N
• exencephaly penetrance was 0% unlike in other genetic backgrounds
abnormal neural tube morphology ( J:177709 )
• increased cranial neural tube width
delayed neural tube closure ( J:177709 )
• at the 16 somite stage the neural tube is closed in only about half the embryos
exencephaly ( J:177709 )
• penetrance is 1.6% at greater than N10

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:177709 )
N
• no cochlear defects are detected

embryo
abnormal neural tube morphology ( J:177709 )
• increased cranial neural tube width
delayed neural tube closure ( J:177709 )
• at the 16 somite stage the neural tube is closed in only about half the embryos

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT anencephaly DOID:0060668 OMIM:206500
 J:96325




Genotype
MGI:3574274
hm4
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:96325 )
• most homozygous mutants die perinatally, however 7.5% of homozgygotes are found at weaning and these are indistinguishable from wildtype

vision/eye
absent eyelids ( J:96325 )
• some homozygous mutants lacked eyelids

nervous system
exencephaly ( J:96325 )
• neural tube defect exencephaly was observed at a frequency of 67% in homozygotes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
anencephaly DOID:0060668 OMIM:206500
 J:96325




Genotype
MGI:3574276
hm5
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:96325 )
• 36% penetrance of exencephaly




Genotype
MGI:3574280
hm6
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background		 involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:96325 )
• exencephaly appeared only in one in 35 homozygous mutant embryos




Genotype
MGI:5297953
ht7
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2+
Genetic
Background		 C.129P2-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
delayed neural tube closure ( J:177709 )
• at the 14 and 16 somite pair stage the percentage of mice with a closed neural tube is decreased compared to wild-type controls

embryo
delayed neural tube closure ( J:177709 )
• at the 14 and 16 somite pair stage the percentage of mice with a closed neural tube is decreased compared to wild-type controls




Genotype
MGI:3574275
ht8
Allelic
Composition		 Cecr2Gt(pGT1)1Hemc/Cecr2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (2 available); any Cecr2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:96325 )
• observed exencephaly at a low frequency of 3.5% in heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory