Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation
(0 available);
any
Notch1 mutation
(115 available)
Notch2tm1Frad mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
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• hair pigmentation is even more reduced with complete absence of Notch1 and 2 in melanocytes: hair is almost white
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integument
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• hair pigmentation is even more reduced with complete absence of Notch1 and 2 in melanocytes: hair is almost white
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation
(0 available);
any
Notch1 mutation
(115 available)
Notch2tm1Frad mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
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N |
• pigmentation mediated by non-follicular melanocytes such as in the ear or eye is not affected by this mutation
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• when crossed to transgenic mice to visualize melanoblasts and melanocytes (dopachrome tautomerase - LacZ mice), at 9 days of age, a decreased number of melanocytes in the lower permanent portion of the hair follicle is observed; differences are greater at 3 and 4.5 weeks with most follicles lacking melanocytes
• mutant hair bulbs lack pigment after their first regeneration
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• coat is completetly gray with coat slightly lighter in color compared to mice missing both Notch2 alleles and one Notch1 allele
• dilution is progressive and increases with age; there is an increasing number of gray and white hairs with age such that at 7 days coat color is indistinguishable from controls, but at 7 months, coat is completely white
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integument
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• when crossed to transgenic mice to visualize melanoblasts and melanocytes (dopachrome tautomerase - LacZ mice), at 9 days of age, a decreased number of melanocytes in the lower permanent portion of the hair follicle is observed; differences are greater at 3 and 4.5 weeks with most follicles lacking melanocytes
• mutant hair bulbs lack pigment after their first regeneration
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• coat is completetly gray with coat slightly lighter in color compared to mice missing both Notch2 alleles and one Notch1 allele
• dilution is progressive and increases with age; there is an increasing number of gray and white hairs with age such that at 7 days coat color is indistinguishable from controls, but at 7 months, coat is completely white
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation
(0 available);
any
Notch1 mutation
(115 available)
Notch2tm1Frad mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
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• at 8 weeks, dispersed gray hairs are observed
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integument
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• at 8 weeks, dispersed gray hairs are observed
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation
(0 available);
any
Notch1 mutation
(115 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
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• dispersed gray hairs are observed, identical to Notch2 mutants or Notch1/Notch2 double heterozygotes, but first gray hairs are only visible at 12 weeks
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integument
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• dispersed gray hairs are observed, identical to Notch2 mutants or Notch1/Notch2 double heterozygotes, but first gray hairs are only visible at 12 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpjtm1Hon mutation
(2 available);
any
Rbpj mutation
(193 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
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N |
• loss of one allele has no affect on coat color; no graying or dilution is observed in 8-week old mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpjtm1Hon mutation
(2 available);
any
Rbpj mutation
(193 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
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N |
• pigmentation mediated by non-follicular melanocytes such as in the ear or eye is not affected by this mutation
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• almost complete hair whitening is observed
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integument
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• almost complete hair whitening is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm1Frad mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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|
|
pigmentation
|
N |
• loss of one allele has no affect on coat color; no graying or dilution is observed in 8-week old mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation
(0 available);
any
Notch1 mutation
(115 available)
Notch2tm1Frad mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
|
|
|
pigmentation
|
N |
• pigmentation mediated by non-follicular melanocytes such as in the ear or eye is not affected by this mutation
|
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• coat is completetly gray
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integument
|
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• coat is completetly gray
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm1Frad mutation
(0 available);
any
Notch2 mutation
(97 available)
Tg(Tyr-cre)2Lru mutation
(0 available)
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pigmentation
|
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• at 8 weeks, dispersed gray hairs are observed
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integument
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• at 8 weeks, dispersed gray hairs are observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-cre)2Lru mutation
(0 available)
Washc5tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Washc5 mutation
(57 available)
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pigmentation
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N |
• mice exhibit normal coat color on the abdomen and extremities, melanocyte stem cells and renewal
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• enlarged, clustered WASH- and WAFL-positive vesicles
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Analysis Tools