Analysis Tools
reproductive system
azoospermia
(
J:96769
)
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• seminiferous tubule contain Sertoli cells and spermatogonia but no spermatids
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• at 5 weeks of age mutant testes are about half the weight of wild-type and the weight difference increases with age
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• synaptonemal complexes are shortened, sister chromatid cohesion is impaired, fewer crossover complexes are seen similar to defects seen in male meiosis
• unlike in males, oocytes progress through meiosis I to dictyate arrest, but defective cohesion results in massive aneuploidy during meiotic divisions
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• the prophase axial elements are shorter, chromosome synapsis is incomplete, sister chromatid cohesion is lost prematurely, telomere attachment is impaired, and crossover complexes are not seen
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• spermatogenesis is arrested by the mid-pachytene stage and increased numbers of apoptotic cells are seen at P17
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infertility
(
J:96769
)
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• both male and female homozygotes are infertile
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endocrine/exocrine glands
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• at 5 weeks of age mutant testes are about half the weight of wild-type and the weight difference increases with age
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cellular
azoospermia
(
J:96769
)
|
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• seminiferous tubule contain Sertoli cells and spermatogonia but no spermatids
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