Analysis Tools
mortality/aging
|
• Background Sensitivity: mice on a C57BL/6 background all die by 2 - 3 weeks of age, unlike mice on a CD-1 background that survive for several months
|
immune system
|
• abnormal lymphatic drainage and functional failure due to a failure in remodeling of the lymphatic capillary plexus and defective valve formation that allows retrograde flow
|
|
• before the appearance of chylothorax, chylous fluid was often detected in lymphatic vessels in the thoracic area, such as in the lymphatics on the heart pericardium and on the rib cage, implying leakage or backflow of lymph
• several mutant mice had red blood cells in the lymphatic vessels
• early capillary plexus of the ventral skin and ear skin developed normally but the subsequent development into a hierarchical network failed
• superficial lymphatic capillaries were hyperplastic and partially covered with smooth muscle cells at P21 but not at p5 compared to no coverage in control capillaries at any time
• extension of the endothelial cell sprouting from vessels was disturbed, resulting in blunt-ended protrusions
|
|
• hyperplastic and unvalved collecting lymphatic vessels
• failure in the specification of collecting lymphatic vessel identity
|
cardiovascular system
|
• abnormal lymphatic drainage and functional failure due to a failure in remodeling of the lymphatic capillary plexus and defective valve formation that allows retrograde flow
|
homeostasis/metabolism
chylothorax
(
J:95885
)
|
• homozygous mutants frequently had effusion of clear chyle from the thoracic duct into the pleural space
|
respiratory system
chylothorax
(
J:95885
)
|
• homozygous mutants frequently had effusion of clear chyle from the thoracic duct into the pleural space
|
