About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(Gphb5)Lmac
targeted mutation 1, Lynn E Macdonald
MGI:3573780
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gt(ROSA)26Sortm1(Gphb5)Lmac/Gt(ROSA)26Sor+ Not Specified MGI:3575743


Genotype
MGI:3575743
ht1
Allelic
Composition
Gt(ROSA)26Sortm1(Gphb5)Lmac/Gt(ROSA)26Sor+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gphb5)Lmac mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• heart rate, diastolic and systolic blood pressure, and pulse pressure tend to be slightly elevated but are within normal limits

craniofacial
• the frontal bone is significantly shorter; however the parietal bone is normal
• the nasal bone is significantly shorter

growth/size/body
• the nasal bone is significantly shorter
• first seen at about 1 month of age but transgenics tend to eat slightly more than wild-type mice
• when placed on a high fat diet male and to a lesser extent female transgenic gain less weight and adipose tissue than wild-type mice

homeostasis/metabolism
• when placed on a high fat diet male and to a lesser extent female transgenic gain less weight and adipose tissue than wild-type mice
• increased 1.5- to 2-fold in both males and females; however, TSH levels were not increased
• increased 1.5- to 2-fold in both males and females; however, TSH levels were not increased
• transgenics consume more oxygen per unit body weight compared to wild-type mice on either a normal or high fat diet

skeleton
• the frontal bone is significantly shorter; however the parietal bone is normal
• the nasal bone is significantly shorter

respiratory system
• the nasal bone is significantly shorter





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory