Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Att mutation
(1 available);
any
Trp53 mutation
(232 available)
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cellular
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• similar to Trp53 null cells, the percentage of cells in S phase is increased compared to wild-type cells
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• in the absence of cre, MEFs are refractory to stress-induced cell death
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Att mutation
(1 available);
any
Trp53 mutation
(232 available)
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cellular
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• there is only a small reduction in the number of cells in S phase following adenoviral cre infection, and this percentage is still higher than in wild-type MEFs
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• MEFs infected with adenoviral cre and treated with doxorubicin show only a moderate decrease in the percentage of cells in S phase indicating an impaired G1 arrest response
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• cell cycle is not arrested by gamma irradiation after treatment with adenovirus-cre
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• following adenoviral cre infection, MEFs remain refractory to UV-C-induced cell death but not hypoxia-induced cell death
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cellular
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• no apoptosis in mice treated with tamoxifen measured 6 hours after radiation treatment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-cre)5132Jlj mutation
(1 available)
Trp53tm1Att mutation
(1 available);
any
Trp53 mutation
(232 available)
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pigmentation
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• mice exhibit markedly darkened ears relative to control mice
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• mice exhibit markedly darkened hair relative to control mice
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• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
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• mice exhibit markedly darkened tails relative to control mice
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integument
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• mice exhibit markedly darkened ears relative to control mice
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• mice exhibit markedly darkened hair relative to control mice
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• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
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• mice exhibit markedly darkened tails relative to control mice
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limbs/digits/tail
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• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
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• mice exhibit markedly darkened tails relative to control mice
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craniofacial
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• mice exhibit markedly darkened ears relative to control mice
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hearing/vestibular/ear
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• mice exhibit markedly darkened ears relative to control mice
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growth/size/body
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• mice exhibit markedly darkened ears relative to control mice
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Analysis Tools