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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdm16Gt(OST67423)Lex
gene trap OST67423, Lexicon Genetics
MGI:3531188
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609829
ht2
 		Prdm16Gt(OST67423)Lex/Prdm16+ involves: 129S5/SvEvBrd * C57BL/6J MGI:3609831
ht3
 		Prdm16csp1/Prdm16Gt(OST67423)Lex involves: 129S5/SvEvBrd * BALB/c * C57BL/6J * FVB/NJ MGI:4437290


Genotype
MGI:3609829
hm1
Allelic
Composition		 Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm16Gt(OST67423)Lex mutation (2 available); any Prdm16 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:103485 )
• homozygous mice display embryonic or perinatal lethality
prenatal lethality, incomplete penetrance ( J:103485 )
• homozygous mice display embryonic or perinatal lethality

craniofacial
cleft secondary palate ( J:157112 )
• wide cleft of the secondary palate
abnormal tongue morphology ( J:157112 )
• abnormal morphology of the tongue
abnormal tongue position ( J:157112 )
• abnormal positioning of the tongue
pointed snout ( J:157112 )
• pointed snout

digestive/alimentary system
cleft secondary palate ( J:157112 )
• wide cleft of the secondary palate
abnormal tongue morphology ( J:157112 )
• abnormal morphology of the tongue
abnormal tongue position ( J:157112 )
• abnormal positioning of the tongue

cardiovascular system
abnormal heart morphology ( J:157112 )
• may display a severe cleft between the ventricles

growth/size/body
cleft secondary palate ( J:157112 )
• wide cleft of the secondary palate
abnormal tongue morphology ( J:157112 )
• abnormal morphology of the tongue
abnormal tongue position ( J:157112 )
• abnormal positioning of the tongue
pointed snout ( J:157112 )
• pointed snout




Genotype
MGI:3609831
ht2
Allelic
Composition		 Prdm16Gt(OST67423)Lex/Prdm16+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm16Gt(OST67423)Lex mutation (2 available); any Prdm16 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased leukocyte cell number ( J:103485 )
• mean white blood cell count is increased

hematopoietic system
increased leukocyte cell number ( J:103485 )
• mean white blood cell count is increased




Genotype
MGI:4437290
ht3
Allelic
Composition		 Prdm16csp1/Prdm16Gt(OST67423)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * BALB/c * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm16csp1 mutation (1 available); any Prdm16 mutation (73 available)
Prdm16Gt(OST67423)Lex mutation (2 available); any Prdm16 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:157112 )
• phenotype is stated to be identical to that of either homozygote

digestive/alimentary system
cleft secondary palate ( J:157112 )
• phenotype is stated to be identical to that of either homozygote

growth/size/body
cleft secondary palate ( J:157112 )
• phenotype is stated to be identical to that of either homozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory