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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Heg1+
wild type
MGI:3530872
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Heg1tm1.1(KOMP)Vlcg/Heg1+ C57BL/6N-Heg1tm1.1(KOMP)Vlcg/J MGI:6480476
cx2
 		Ccm2Gt(RRG051)Byg/Ccm2+
Heg1tm1Mlkn/Heg1+ 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3838394


Genotype
MGI:6480476
ht1
Allelic
Composition		 Heg1tm1.1(KOMP)Vlcg/Heg1+
Genetic
Background		 C57BL/6N-Heg1tm1.1(KOMP)Vlcg/J
Cell Lines 13548A-D3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Heg1tm1.1(KOMP)Vlcg mutation (1 available); any Heg1 mutation (56 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Genotype
MGI:3838394
cx2
Allelic
Composition		 Ccm2Gt(RRG051)Byg/Ccm2+
Heg1tm1Mlkn/Heg1+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation (0 available); any Ccm2 mutation (46 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal dorsal aorta morphology ( J:146528 )
• the paired dorsal aortas are small or undetectable and completely lack luminal blood at E9
abnormal cardinal vein morphology ( J:146528 )
• when visible the cardinal veins are devoid of luminal blood except at the point where it attaches to the sinus venosus
abnormal vascular endothelial cell development ( J:146528 )
• endothelial cells are present but fail to form lumenized vessels
abnormal vasculogenesis ( J:146528 )
• fail to form lumenized vessels
dilated aortic sac ( J:146528 )
• a dilated aortic sac is seen at E9
hemopericardium ( J:146528 )
• blood cells are frequently detected in the pericardial cavity
pericardial edema ( J:146528 )
• starting at E9

embryo
embryonic growth retardation ( J:146528 )
• starting at E9

homeostasis/metabolism
hemopericardium ( J:146528 )
• blood cells are frequently detected in the pericardial cavity
pericardial edema ( J:146528 )
• starting at E9

growth/size/body
embryonic growth retardation ( J:146528 )
• starting at E9




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory