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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lim2Gt(OST98930)Lex
gene trap OST98930, Lexicon Genetics
MGI:3530610
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lim2Gt(OST98930)Lex/Lim2Gt(OST98930)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3719076


Genotype
MGI:3719076
hm1
Allelic
Composition
Lim2Gt(OST98930)Lex/Lim2Gt(OST98930)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lim2Gt(OST98930)Lex mutation (0 available); any Lim2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the radii of curvature of the refractive surface is smaller
• lenses complete disintegrate when bisected suggesting a lack of tissue cohesion
• when a grid is observed through the lens it is distorted compared to when a wild-type lens is used and dark annulus are observed
• mice possess two refractive compartments compared to one in wild-type resulting in altered refractive properties
• at 3 weeks, mice develop faint, hazy opacities centered in the fetal nuclear region and by 12 weeks, discrete nuclear crumbling opacities are observed
• back vertex distance (BVD) is shorter in the cortex of the lens and slightly greater in the perinuclear region indicating that the refractive power for the cortex is greater and that of the perinuclear region is less
• lens diameter is smaller at 6 months of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory