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Allele Symbol Allele Name Allele ID |
Mtfr1Gt(OST6261)Lex gene trap OST6261, Lexicon Genetics MGI:3530581 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• testis tissue exhibit 2 times the amount of oxidative DNA damage than wild-type mice
• however, other organs such as the liver and lung do not exhibit an increase in oxidative DNA damage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• overall ATP production in the testes is 2.5 times less than in wild-type mice
• testes from 6-month old mutants shows a reduction in mitochondrial oxygen consumption compared to controls; 2-fold and 3-fold reduction in oxygen consumption for the I + III + IV and the II + III + IV mitochondrial complexes, respectively
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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