Phenotypes associated with this allele

• Allele Symbol: Tg(Atp4b-TAg)#Jig
• Allele Name: transgene insertion, Jeffrey I Gordon
• Allele ID: MGI:3530509
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Atp4b-TAg)#Jig/0	involves: FVB/N	MGI:3040899

Genotype
MGI:3040899

tg1

• Allelic Composition: Tg(Atp4b-TAg)#Jig/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased stomach tumor incidence ( J:89240 )

• invasive gastric carcinoma is observed in 60% of mice at 48 weeks of age and is seen in all mice by 1 year of age

increased carcinoma incidence ( J:89240 )

• invasive gastric carcinoma is observed in 60% of mice at 48 weeks of age and is seen in all mice by 1 year of age

digestive/alimentary system

abnormal gastric parietal cell morphology ( J:89240 )

• 50- to 70-fold increase in the number of rare preparietal cells by 12 weeks of age

increased stomach mucosa thickness ( J:89240 )

• progressive epithelial thickening between 12 and 32 weeks of age produced by preparietal cell hyperplasia

gastric cyst ( J:89240 )

• mutants between 12 and 32 weeks of age exhibit cyst formation

gastric metaplasia ( J:89240 )

• transdifferentiation of parietal cell progenitors to a neuroendocrine phenotype

increased stomach tumor incidence ( J:89240 )

• invasive gastric carcinoma is observed in 60% of mice at 48 weeks of age and is seen in all mice by 1 year of age

endocrine/exocrine glands

abnormal gastric parietal cell morphology ( J:89240 )

• 50- to 70-fold increase in the number of rare preparietal cells by 12 weeks of age

growth/size/body

gastric cyst ( J:89240 )

• mutants between 12 and 32 weeks of age exhibit cyst formation