About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtn4rtm1Matl
targeted mutation 1, Marc Tessier-Lavigne
MGI:3530480
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rtn4rtm1Matl/Rtn4rtm1Matl involves: 129S7/SvEvBrd MGI:4867905
hm2
 		Rtn4rtm1Matl/Rtn4rtm1Matl involves: 129S7/SvEvBrd * C57BL/6 MGI:3531403


Genotype
MGI:4867905
hm1
Allelic
Composition		 Rtn4rtm1Matl/Rtn4rtm1Matl
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rtm1Matl mutation (1 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal response to CNS ischemic injury ( J:166895 )
• the number of axons in peri-infarct cortex after stroke is increased compared to in similarly treated wild-type mice

nervous system
abnormal response to CNS ischemic injury ( J:166895 )
• the number of axons in peri-infarct cortex after stroke is increased compared to in similarly treated wild-type mice




Genotype
MGI:3531403
hm2
Allelic
Composition		 Rtn4rtm1Matl/Rtn4rtm1Matl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rtm1Matl mutation (1 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:96121 )
N
• no differences in the inhibition of neurite outgrowth of postnatal dorsal root ganglion or cerebellar granule neurons by myelin or by a Nogo-66 (Rtn4) substrate compared to heterozygous controls
• homozygotes did not show enhanced regeneration of corticospinal tract axons in comparison with wild-type controls after spinal dorsal hemisection, indicating that Rtn4r does not play a central role in mediating axonal growth inhibition




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory