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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr65tm1Witt
targeted mutation 1, Owen N Witte
MGI:3530470
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr65tm1Witt/Gpr65tm1Witt B6.Cg-Gpr65tm1Witt MGI:3576046
hm2
 		Gpr65tm1Witt/Gpr65tm1Witt C.Cg-Gpr65tm1Witt MGI:3576047


Genotype
MGI:3576046
hm1
Allelic
Composition		 Gpr65tm1Witt/Gpr65tm1Witt
Genetic
Background		 B6.Cg-Gpr65tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr65tm1Witt mutation (1 available); any Gpr65 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune cell physiology ( J:96112 )
• production of cAMP by total splenocytes was insensitive to pH
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes

hematopoietic system
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes




Genotype
MGI:3576047
hm2
Allelic
Composition		 Gpr65tm1Witt/Gpr65tm1Witt
Genetic
Background		 C.Cg-Gpr65tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr65tm1Witt mutation (1 available); any Gpr65 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes

hematopoietic system
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory